Role of Mdm2 and Mdmx in DNA repair

被引：31

作者：

Eischen, Christine M. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Canc Biol, Sidney Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

JOURNAL OF MOLECULAR CELL BIOLOGY | 2017年 / 9卷 / 01期

关键词：

Mdm2; Mdmx; Nbs1; DNA repair; MYC-INDUCED LYMPHOMAGENESIS; STRAND-BREAK REPAIR; P53-DEFICIENT CELLS; EMBRYONIC LETHALITY; CHROMOSOME INSTABILITY; P53-INDEPENDENT ROLE; GENOMIC INSTABILITY; MDM2-DEFICIENT MICE; DAMAGE RESPONSE; CANCER CELLS;

D O I：

10.1093/jmcb/mjw052

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mdm2 and Mdmx are critical regulators of the p53 tumour suppressor and are overexpressed in many human malignancies. However, in recent years, their impact on genome instability was shown to be at least, in part, independent of p53. Both Mdm2 and Mdmx inhibit DNA break repair through their association with the Mre11/Rad50/Nbs1 DNA repair complex. Recent evidence indicates that harnessing Mdm2 and/or Mdmx-mediated inhibition of DNA break repair in cancer cells could provide a therapeutic opportunity, particularly for those malignancies that have lost functional p53.

引用

页码：69 / 73

页数：5

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