The transcription factors Emx1 and Emx2 suppress choroid plexus development and promote neuroepithelial cell fate

被引:27
|
作者
von Frowein, Julia
Wizenmann, Andrea
Goetz, Magdalena
机构
[1] GSF Munich, Natl Res Ctr Environm & Hlth, Inst Stem Cell Res, D-85764 Munich, Germany
[2] Univ Munich, Inst Physiol, Munich, Germany
[3] Univ Munich, Dr Von Haunerschen Kinderspital, D-80337 Munich, Germany
关键词
telencephalon; cortical hem; midline; roof plate; patterning; Emx1; Emx2; DORSAL TELENCEPHALIC MIDLINE; EMBRYONIC CEREBRAL-CORTEX; GENE-EXPRESSION; HOMEOBOX GENES; NEURONAL DIFFERENTIATION; NERVOUS-SYSTEM; PAX6; FUNCTION; BETA-CATENIN; MUTANT MICE; RADIAL GLIA;
D O I
10.1016/j.ydbio.2006.04.461
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The transcription factors Emx1 and Emx2 exert important functions during development of the cerebral cortex, including its arealization. Here, we addressed their role in development of the derivatives of the midline region in the telencephalon. The center of the midline region differentiates into the choroid plexus, but little is known about its molecular specification. As we noted a lack of Emx1 or 2 expression in the midline region early in development, we interfered by misexpressing Emx1 and/or Emx2 in this region of the chick telencephalon. Ectopic expression of either Emx1 or Emx2 prior to HH 13 instructed a neuroepithelial identity in the previous midline region instead of a choroidal fate. Thus, Gli3 and Lhx2 normally restricted to the neuroepithelium expanded into the Emx misexpressing region. This was accompanied by down-regulation of Otx2 and BMP7, which implicates that these factors are essential for choroid plexus specification and differentiation. Interestingly, the region next to the ectopic Emx-misexpression then acquired a hybrid identity with some choroidal features such as Bmp7, Otx2 and Ttr gene expression, as well as some neuroepithelial features. These observations indicate that the expression levels of Emx1 and/or Emx2 restrict the prospective choroid plexus territory, a novel role of these transcription factors. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:239 / 252
页数:14
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