Background: The cerebellum is an important site for cortical demyelination in multiple sclerosis, but the functional significance of this finding is not fully understood. Objective: To evaluate the clinical and cognitive impact of cerebellar grey-matter pathology in multiple sclerosis patients. Methods: Forty-two relapsing-remitting multiple sclerosis patients and 30 controls underwent clinical assessment including the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale (EDSS) and cerebellar functional system (FS) score, and cognitive evaluation, including the Paced Auditory Serial Addition Test (PASAT) and the Symbol-Digit Modalities Test (SDMT). Magnetic resonance imaging was performed with a 3T scanner and variables of interest were: brain white-matter and cortical lesion load, cerebellar intracortical and leukocortical lesion volumes, and brain cortical and cerebellar white-matter and grey-matter volumes. Results: After multivariate analysis high burden of cerebellar intracortical lesions was the only predictor for the EDSS (p<0.001), cerebellar FS (p = 0.002), arm function (p = 0.049), and for leg function (p<0.001). Patients with high burden of cerebellar leukocortical lesions had lower PASAT scores (p = 0.013), while patients with greater volumes of cerebellar intracortical lesions had worse SDMT scores (p = 0.015). Conclusions: Cerebellar grey-matter pathology is widely present and contributes to clinical dysfunction in relapsing-remitting multiple sclerosis patients, independently of brain grey-matter damage.
机构:
CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Cerasa, Antonio
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Valentino, Paola
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Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Valentino, Paola
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Chiriaco, Carmelina
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Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Chiriaco, Carmelina
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Pirritano, Domenico
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机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Pirritano, Domenico
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Nistico, Rita
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CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Nistico, Rita
;
Gioia, Cecilia M.
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CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Gioia, Cecilia M.
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Trotta, Maria
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机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Trotta, Maria
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Del Giudice, Francesco
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机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Del Giudice, Francesco
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Tallarico, Tiziana
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h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Tallarico, Tiziana
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Rocca, Federico
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机构:
CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Rocca, Federico
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Augimeri, Antonio
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机构:
CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Augimeri, Antonio
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Bilotti, Giacinta
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机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Bilotti, Giacinta
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Quattrone, Aldo
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机构:
CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
机构:
Queens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, EnglandQueens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
Gilmore, C. P.
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Donaldson, I.
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机构:Queens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
Donaldson, I.
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Bo, L.
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机构:
VU Med Ctr, Dept Neuropathol, Amsterdam, Netherlands
Haukeland Hosp, Dept Neurol, Natl Competence Ctr MS, N-5021 Bergen, NorwayQueens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
Bo, L.
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Owens, T.
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机构:
Univ Nottingham, Dept Econ, Nottingham NG7 2RD, EnglandQueens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
Owens, T.
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Lowe, J.
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机构:
Univ Nottingham, Dept Neuropathol, Nottingham NG7 2RD, EnglandQueens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
Lowe, J.
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Evangelou, N.
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h-index: 0
机构:Queens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
机构:
CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Cerasa, Antonio
;
Valentino, Paola
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机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Valentino, Paola
;
Chiriaco, Carmelina
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h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Chiriaco, Carmelina
;
Pirritano, Domenico
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机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Pirritano, Domenico
;
Nistico, Rita
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机构:
CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Nistico, Rita
;
Gioia, Cecilia M.
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h-index: 0
机构:
CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Gioia, Cecilia M.
;
Trotta, Maria
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h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Trotta, Maria
;
Del Giudice, Francesco
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h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Del Giudice, Francesco
;
Tallarico, Tiziana
论文数: 0引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Tallarico, Tiziana
;
Rocca, Federico
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h-index: 0
机构:
CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Rocca, Federico
;
Augimeri, Antonio
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机构:
CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Augimeri, Antonio
;
Bilotti, Giacinta
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h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Bilotti, Giacinta
;
Quattrone, Aldo
论文数: 0引用数: 0
h-index: 0
机构:
CNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
Magna Graecia Univ Catanzaro, Dept Med Sci, Inst Neurol, Catanzaro, ItalyCNR, Neuroimaging Res Unit, Inst Neurol Sci, I-88100 Germaneto, CZ, Italy
机构:
Queens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, EnglandQueens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
Gilmore, C. P.
;
Donaldson, I.
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机构:Queens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
Donaldson, I.
;
Bo, L.
论文数: 0引用数: 0
h-index: 0
机构:
VU Med Ctr, Dept Neuropathol, Amsterdam, Netherlands
Haukeland Hosp, Dept Neurol, Natl Competence Ctr MS, N-5021 Bergen, NorwayQueens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
Bo, L.
;
Owens, T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nottingham, Dept Econ, Nottingham NG7 2RD, EnglandQueens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
Owens, T.
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Lowe, J.
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h-index: 0
机构:
Univ Nottingham, Dept Neuropathol, Nottingham NG7 2RD, EnglandQueens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England
Lowe, J.
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Evangelou, N.
论文数: 0引用数: 0
h-index: 0
机构:Queens Med Ctr NHS Trust, B Floor Med Sch, Dept Neurol, Nottingham NG7 2UH, England