The Clinical Impact of Cerebellar Grey Matter Pathology in Multiple Sclerosis

被引:41
作者
Damasceno, Alfredo [1 ]
Damasceno, Benito Pereira [1 ]
Cendes, Fernando [1 ]
机构
[1] Univ Campinas UNICAMP, Dept Neurol, Campinas, Brazil
来源
PLOS ONE | 2014年 / 9卷 / 05期
基金
巴西圣保罗研究基金会;
关键词
SURFACE-BASED ANALYSIS; CEREBRAL-CORTEX; LESIONS; ATROPHY; MS; DEMYELINATION; IMPAIRMENT; EXTENT; MRI;
D O I
10.1371/journal.pone.0096193
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: The cerebellum is an important site for cortical demyelination in multiple sclerosis, but the functional significance of this finding is not fully understood. Objective: To evaluate the clinical and cognitive impact of cerebellar grey-matter pathology in multiple sclerosis patients. Methods: Forty-two relapsing-remitting multiple sclerosis patients and 30 controls underwent clinical assessment including the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale (EDSS) and cerebellar functional system (FS) score, and cognitive evaluation, including the Paced Auditory Serial Addition Test (PASAT) and the Symbol-Digit Modalities Test (SDMT). Magnetic resonance imaging was performed with a 3T scanner and variables of interest were: brain white-matter and cortical lesion load, cerebellar intracortical and leukocortical lesion volumes, and brain cortical and cerebellar white-matter and grey-matter volumes. Results: After multivariate analysis high burden of cerebellar intracortical lesions was the only predictor for the EDSS (p<0.001), cerebellar FS (p = 0.002), arm function (p = 0.049), and for leg function (p<0.001). Patients with high burden of cerebellar leukocortical lesions had lower PASAT scores (p = 0.013), while patients with greater volumes of cerebellar intracortical lesions had worse SDMT scores (p = 0.015). Conclusions: Cerebellar grey-matter pathology is widely present and contributes to clinical dysfunction in relapsing-remitting multiple sclerosis patients, independently of brain grey-matter damage.
引用
收藏
页数:7
相关论文
共 21 条
[1]   A comprehensive assessment of cerebellar damage in multiple sclerosis using diffusion tractography and volumetric analysis [J].
Anderson, V. M. ;
Wheeler-Kingshott, C. A. M. ;
Abdel-Aziz, K. ;
Miller, D. H. ;
Toosy, A. ;
Thompson, A. J. ;
Ciccarelli, O. .
MULTIPLE SCLEROSIS JOURNAL, 2011, 17 (09) :1079-1087
[2]   Magnetic resonance evidence of cerebellar cortical pathology in multiple sclerosis [J].
Calabrese, Massimiliano ;
Mattisi, Irene ;
Rinaldi, Francesca ;
Favaretto, Alice ;
Atzori, Matteo ;
Bernardi, Valentina ;
Barachino, Luigi ;
Romualdi, Chiara ;
Rinaldi, Luciano ;
Perini, Paola ;
Gallo, Paolo .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 (04) :401-404
[3]  
Calabrese M, 2009, ARCH NEUROL-CHICAGO, V66, P1144, DOI 10.1001/archneurol.2009.174
[4]   MR imaging and cognitive correlates of relapsing-remitting multiple sclerosis patients with cerebellar symptoms [J].
Cerasa, Antonio ;
Valentino, Paola ;
Chiriaco, Carmelina ;
Pirritano, Domenico ;
Nistico, Rita ;
Gioia, Cecilia M. ;
Trotta, Maria ;
Del Giudice, Francesco ;
Tallarico, Tiziana ;
Rocca, Federico ;
Augimeri, Antonio ;
Bilotti, Giacinta ;
Quattrone, Aldo .
JOURNAL OF NEUROLOGY, 2013, 260 (05) :1358-1366
[5]   Cortical surface-based analysis - I. Segmentation and surface reconstruction [J].
Dale, AM ;
Fischl, B ;
Sereno, MI .
NEUROIMAGE, 1999, 9 (02) :179-194
[6]   Cortical surface-based analysis - II: Inflation, flattening, and a surface-based coordinate system [J].
Fischl, B ;
Sereno, MI ;
Dale, AM .
NEUROIMAGE, 1999, 9 (02) :195-207
[7]   Measuring the thickness of the human cerebral cortex from magnetic resonance images [J].
Fischl, B ;
Dale, AM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (20) :11050-11055
[8]   Consensus recommendations for MS cortical lesion scoring using double inversion recovery MRI [J].
Geurts, J. J. G. ;
Roosendaal, S. D. ;
Calabrese, M. ;
Ciccarelli, O. ;
Agosta, F. ;
Chard, D. T. ;
Gass, A. ;
Huerga, E. ;
Moraal, B. ;
Pareto, D. ;
Rocca, M. A. ;
Wattjes, M. P. ;
Yousry, T. A. ;
Uitdehaag, B. M. J. ;
Barkhof, F. .
NEUROLOGY, 2011, 76 (05) :418-424
[9]   Measurement and clinical effect of grey matter pathology in multiple sclerosis [J].
Geurts, Jeroen J. G. ;
Calabrese, Massimiliano ;
Fisher, Elizabeth ;
Rudick, Richard A. .
LANCET NEUROLOGY, 2012, 11 (12) :1082-1092
[10]   Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord [J].
Gilmore, C. P. ;
Donaldson, I. ;
Bo, L. ;
Owens, T. ;
Lowe, J. ;
Evangelou, N. .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2009, 80 (02) :182-187