Acute toxicity evaluation for quinolone antibiotics and their chlorination disinfection processes

被引:39
作者
Li, Min [1 ,2 ]
Wei, Dongbin [1 ]
Du, Yuguo [1 ,2 ]
机构
[1] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
基金
中国国家自然科学基金;
关键词
Quinolones; Acute toxicity; QSAR; Mechanism; Chlorination; FLUOROQUINOLONE ANTIBACTERIAL AGENTS; SOLID-PHASE EXTRACTION; WASTE-WATER; ENVIRONMENTAL EXPOSURE; IDENTIFICATION; ANTIMICROBIALS; CIPROFLOXACIN; MECHANISMS; SEWAGE; PLANTS;
D O I
10.1016/j.jes.2014.06.023
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Acute toxicity of 21 quinolone antibiotics was monitored using photobacterium Vibrio fischeri assay. The minimum IC20 (inhibitory concentration for 20% luminescence elimination) was obtained at the least 18.86 mu mol/L for the tested quinolones. A quantitative structure-activity relationship model was established to investigate the possible mechanism for the acute toxicity. The critical physicochemical descriptors, describing sigma and pi atom electronegativity, implied that the electron transfer might occur between the quinolones and photobacterium V. fischeri. Although the quinolones exhibited limited acute toxicity to photobacterium, toxicity elevation was detected after their chlorination. Hence, chlorination disinfection treatment of quinolone-containing water should be of concerns. (C) 2014 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
引用
收藏
页码:1837 / 1842
页数:6
相关论文
共 29 条
[1]  
[Anonymous], 2006, STANDARD METHODS EXA, DOI DOI 10.5860/CHOICE.37-2792
[2]   The single substance and mixture toxicity of quinolones to the bioluminescent bacterium Vibrio fischeri [J].
Backhaus, T ;
Scholze, M ;
Grimme, LH .
AQUATIC TOXICOLOGY, 2000, 49 (1-2) :49-61
[3]  
BRYAN LE, 1989, CLIN INVEST MED, V12, P14
[4]   An overview of sample preparation procedures for LC-MS multiclass antibiotic determination in environmental and food samples [J].
Cruz Moreno-Bondi, Maria ;
Dolores Marazuela, Maria ;
Herranz, Sonia ;
Rodriguez, Erika .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2009, 395 (04) :921-946
[5]   Interactions of fluoroquinolone antibacterial agents with aqueous chlorine: Reaction kinetics, mechanisms, and transformation pathways [J].
Dodd, MC ;
Shah, AD ;
Von Gunten, U ;
Huang, CH .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2005, 39 (18) :7065-7076
[6]   TOXICITY OF THE FLUOROQUINOLONE ANTIBIOTICS ENROFLOXACIN AND CIPROFLOXACIN TO PHOTOAUTOTROPHIC AQUATIC ORGANISMS [J].
Ebert, Ina ;
Bachmann, Jean ;
Kuehnen, Ute ;
Kuester, Anette ;
Kussatz, Carola ;
Maletzki, Dirk ;
Schlueter, Christoph .
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2011, 30 (12) :2786-2792
[7]   Aqueous chlorination of levofloxacin: Kinetic and mechanistic study, transformation product identification and toxicity [J].
El Najjar, Nasma Hamdi ;
Deborde, Marie ;
Journel, Romain ;
Leitner, Nathalie Karpel Vel .
WATER RESEARCH, 2013, 47 (01) :121-129
[8]   Environmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil [J].
Golet, EM ;
Xifra, I ;
Siegrist, H ;
Alder, AC ;
Giger, W .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2003, 37 (15) :3243-3249
[9]   Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley Watershed, Switzerland [J].
Golet, EM ;
Alder, AC ;
Giger, W .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2002, 36 (17) :3645-3651
[10]   Primary DNA damage but not mutagenicity correlates with ciprofloxacin concentrations in German hospital wastewaters [J].
Hartmann, A ;
Golet, EM ;
Gartiser, S ;
Alder, AC ;
Koller, T ;
Widmer, RM .
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1999, 36 (02) :115-119