The effects of 13-cis retinoic acid on squamous cell carcinoma proliferation and adhesion to extracellular matrix proteins

被引：1

作者：

Speyer, MT

Jackson, JA

Burkey, BB

机构：

[1] Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University, Medical Center, Nashville

[2] Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University, Medical Center, Nashville, TN 37267

来源：

LARYNGOSCOPE | 1997年 / 107卷 / 01期

关键词：

13-cis retinoic acid; squamous cell carcinoma; extracellular matrix protein; transforming growth factor beta(1); chemoprevention;

D O I：

10.1097/00005537-199701000-00011

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To understand the role of retinoids in chemoprevention, the authors examined the effects of 13-cis retinoic acid (cRA) on squamous cell carcinoma proliferation and adhesion to extracellular matrix proteins. The antiproliferative effects of cRA were first seen on day 11 (66% inhibition) and progressed through day 19 (96% inhibition). Using an adhesion assay, the authors then investigated the effects of cRA and transforming growth factor-beta(1) (TGF-beta(1)) on cellular adhesion to purified type TV collagen, fibronectin, and laminin matrices. Cells treated for 4 days with TGF-beta(1) increased adhesion by 15% to 29%, and cells treated with cRA increased adhesion by 19% to 39%. However, the use of cRA alone resulted in a decrease in adhesion when tumor cells were treated for 7 days (20% to 32%) and 15 days (25% to 40%). The authors also discuss how cRA acts as a differentiating agent on squamous cell carcinoma.

引用

页码：44 / 48

页数：5