The Absolute Configuration of Rhizopodin and Its Inhibition of Actin Polymerization by Dimerization

被引：62

作者：

Hagelueken, Gregor ^{[1
]}

Albrecht, Simone C. ^{[1
]}

Steinmetz, Heinrich ^{[3
,4
]}

Jansen, Rolf ^{[3
,4
]}

Heinz, Dirk W. ^{[2
]}

Kalesse, Markus ^{[3
,4
]}

Schubert, Wolf-Dieter ^{[1
]}

机构：

[1] Helmholtz Ctr Infect Res, Res Grp Mol Host Pathogen Interact, D-38124 Braunschweig, Germany

[2] Helmholtz Ctr Infect Res, Div Struct Biol, D-38124 Braunschweig, Germany

[3] Helmholtz Ctr Infect Res, Dept Microbial Drugs, D-38124 Braunschweig, Germany

[4] Helmholtz Ctr Infect Res, Dept Med Chem, D-38124 Braunschweig, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 03期

关键词：

actin; inhibitors; macrolides; myxobacteria; rhizopodin; BINDING; COMPLEX;

D O I：

10.1002/anie.200802915

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three's company: Rhizopodin is a cytostatic macrolide and a potent actin depolymerizer produced by the myxobacterium Myxococcus stipitatus. A crystal structure analysis of the rhizopodin/actin complex reveals that rhizopodin is a C2-symmetric bislactone (see formula). The ternary complex supports the mode of rhizopodin-induced actin dimerization and reveals the absolute configuration and biologically active conformation of this macrolide. (Chemical Equation Presented) © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：595 / 598

页数：4

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