Preclinical Studies of Stem Cell Therapy for Heart Disease

被引：103

作者：

Tompkins, Bryon A. ^{[1
,2
]}

Balkan, Wayne ^{[1
,3
]}

Winkler, Johannes ^{[4
]}

Gyongyosi, Mariann ^{[4
]}

Goliasch, Georg ^{[4
]}

Fernandez-Aviles, Francisco ^{[5
,6
]}

Hare, Joshua M. ^{[1
,3
]}

机构：

[1] Univ Miami, Miller Sch Med, Interdisciplinary Stem Cell Inst, Biomed Res Bldg,1501 NW 10th Ave,Room 908, Miami, FL 33101 USA

[2] Univ Miami, Miller Sch Med, Dept Surg, Miami, FL 33101 USA

[3] Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33101 USA

[4] Med Univ Vienna, Dept Cardiol, Vienna, Austria

[5] Univ Complutense, Inst Invest Sanitaria Gregorio Maranon, Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[6] ISCIII, CIBERCV, Madrid, Spain

来源：

CIRCULATION RESEARCH | 2018年 / 122卷 / 07期

基金：

美国国家卫生研究院;

关键词：

heart failure; infarction; regenerative medicine; stem cells; ENDOTHELIAL PROGENITOR CELLS; BONE-MARROW-CELLS; ACUTE MYOCARDIAL-INFARCTION; IMPROVES CARDIAC-FUNCTION; ENHANCES COLLATERAL PERFUSION; MESENCHYMAL STROMAL CELLS; LEFT-VENTRICULAR FUNCTION; UMBILICAL-CORD BLOOD; DILATED CARDIOMYOPATHY; ISCHEMIC-HEART;

D O I：

10.1161/CIRCRESAHA.117.312486

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

As part of the TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) series to enhance regenerative medicine, here, we discuss the role of preclinical studies designed to advance stem cell therapies for cardiovascular disease. The quality of this research has improved over the past 10 to 15 years and overall indicates that cell therapy promotes cardiac repair. However, many issues remain, including inability to provide complete cardiac recovery. Recent studies question the need for intact cells suggesting that harnessing what the cells release is the solution. Our contribution describes important breakthroughs and current directions in a cell-based approach to alleviating cardiovascular disease.

引用

页码：1006 / 1020

页数：15

共 50 条

[31] Paracrine mechanisms of stem cell reparative and regenerative actions in the heart
Mirotsou, Maria
Jayawardena, Tilanthi M.
Schmeckpeper, Jeffrey
Gnecchi, Massimiliano
Dzau, Victor J.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2011, 50 (02) : 280 - 289
[32] Stem cell therapy for heart disease-Meta-analysis may be misleading
Huang, Yuli
Mai, Linlin
Cai, Xiaoyan
Hu, Yunzhao
Mai, Weiyi
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2016, 203 : 351 - 352
[33] Stem cell therapy for Crohn's disease: systematic review and meta-analysis of preclinical and clinical studies
Wang, Ruo
Yao, Qigu
Chen, Wenyi
Gao, Feiqiong
Li, Pan
Wu, Jian
Yu, Jiong
Cao, Hongcui
STEM CELL RESEARCH & THERAPY, 2021, 12 (01)
[34] Stem Cell Therapy in Heart Diseases - Cell Types, Mechanisms and Improvement Strategies
Mueller, Paula
Lemcke, Heiko
David, Robert
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 48 (06) : 2607 - 2655
[35] Ethics of stem cell therapy for heart failure
Diaz-Navarro, Rienzi
Perez-Terzic, Carmen
REVISTA MEDICA DE CHILE, 2019, 147 (06) : 787 - 789
[36] Stem Cell Therapy in Cardiovascular Disorders
Krause, Korff
Schneider, Carsten
Kuck, Karl-Heinz
Jaquet, Kai
CARDIOVASCULAR THERAPEUTICS, 2010, 28 (05) : e101 - e110
[37] Stem cell therapy for heart failure: Medical breakthrough, or dead end?
Rheault-Henry, Mathieu
White, Ian
Grover, Diya
Atoui, Rony
WORLD JOURNAL OF STEM CELLS, 2021, 13 (04): : 236 - 259
[38] Stem Cell Therapy for Ischaemic Stroke: Translation from Preclinical Studies to Clinical Treatment
Balami, Joyce S.
Fricker, Rosemary A.
Chen, Ruoli
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2013, 12 (02) : 209 - 219
[39] Stem cell therapy for cardiac dysfunction
Matar, Amer A.
Chong, James J. H.
SPRINGERPLUS, 2014, 3
[40] In Search of the Holy Grail: Stem Cell Therapy as a Novel Treatment of Heart Failure with Preserved Ejection Fraction
Domaszk, Olaf
Skwarek, Aleksandra
Wojciechowska, Malgorzata
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (05)

← 1 2 3 4 5 →