Preclinical Studies of Stem Cell Therapy for Heart Disease

被引：103

作者：

Tompkins, Bryon A. ^{[1
,2
]}

Balkan, Wayne ^{[1
,3
]}

Winkler, Johannes ^{[4
]}

Gyongyosi, Mariann ^{[4
]}

Goliasch, Georg ^{[4
]}

Fernandez-Aviles, Francisco ^{[5
,6
]}

Hare, Joshua M. ^{[1
,3
]}

机构：

[1] Univ Miami, Miller Sch Med, Interdisciplinary Stem Cell Inst, Biomed Res Bldg,1501 NW 10th Ave,Room 908, Miami, FL 33101 USA

[2] Univ Miami, Miller Sch Med, Dept Surg, Miami, FL 33101 USA

[3] Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33101 USA

[4] Med Univ Vienna, Dept Cardiol, Vienna, Austria

[5] Univ Complutense, Inst Invest Sanitaria Gregorio Maranon, Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[6] ISCIII, CIBERCV, Madrid, Spain

来源：

CIRCULATION RESEARCH | 2018年 / 122卷 / 07期

基金：

美国国家卫生研究院;

关键词：

heart failure; infarction; regenerative medicine; stem cells; ENDOTHELIAL PROGENITOR CELLS; BONE-MARROW-CELLS; ACUTE MYOCARDIAL-INFARCTION; IMPROVES CARDIAC-FUNCTION; ENHANCES COLLATERAL PERFUSION; MESENCHYMAL STROMAL CELLS; LEFT-VENTRICULAR FUNCTION; UMBILICAL-CORD BLOOD; DILATED CARDIOMYOPATHY; ISCHEMIC-HEART;

D O I：

10.1161/CIRCRESAHA.117.312486

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

As part of the TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) series to enhance regenerative medicine, here, we discuss the role of preclinical studies designed to advance stem cell therapies for cardiovascular disease. The quality of this research has improved over the past 10 to 15 years and overall indicates that cell therapy promotes cardiac repair. However, many issues remain, including inability to provide complete cardiac recovery. Recent studies question the need for intact cells suggesting that harnessing what the cells release is the solution. Our contribution describes important breakthroughs and current directions in a cell-based approach to alleviating cardiovascular disease.

引用

页码：1006 / 1020

页数：15

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