Trienic -pyrone and ochratoxin derivatives from a sponge-derived fungus Aspergillus ochraceopetaliformis

被引：18

作者：

Liu, Jing-Tang ^{[1
]}

Wu, Wei ^{[1
]}

Cao, Min-Jia ^{[1
]}

Yang, Fan ^{[1
]}

Lin, Hou-Wen ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogenes & Related Genes, Res Ctr Marine Drugs,Dept Pharm,Renji Hosp, Shanghai, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 15期

基金：

中国国家自然科学基金;

关键词：

Sponge-derived fungus; Aspergillus ochraceopetaliformis; trienic; -pyrone; ochratoxin; anti-inflammatory;

D O I：

10.1080/14786419.2017.1402325

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new trienic alpha-pyrone derivative asteltoxin G (1) bearing a tetrahydrofuran ring and a new ochratoxin derivative named ochratoxin A(1) (5), along with seven known compounds, were isolated from a sponge-derived fungus Aspergillus ochraceopetaliformis. The compounds (1-9) were evaluated on the basis of spectroscopic analyses and comparison with those of the reported data. The new compound ochratoxin A(1) (5) exhibited anti-inflammatory activity against IL-6 and TNF-alpha expression of the LPS-induced THP-1 cells with inhibitory rates of 74.4 and 67.7% at concentration of 10 mu M, respectively. [GRAPHICS] .

引用

页码：1791 / 1797

页数：7

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