Pharmacology of bisphosphonates

被引：152
作者：
Cremers, Serge [1 ,2 ]
Drake, Matthew T. [3 ,4 ]
Ebetino, F. Hal [5 ,6 ]
Bilezikian, John P. [2 ]
Russell, R. Graham G. [6 ,7 ]
机构：
[1] Columbia Univ, Irving Med Ctr, Vagelos Coll Phys & Surg, Div Lab Med,Dept Pathol & Cell Biol, New York, NY 10032 USA
[2] Columbia Univ, Irving Med Ctr, Vagelos Coll Phys & Surg, Div Endocrinol,Dept Med, New York, NY USA
[3] Mayo Clin, Coll Med, Dept Endocrinol, Rochester, MN USA
[4] Mayo Clin, Coll Med, Kogod Ctr Aging, Rochester, MN USA
[5] Univ Rochester, Dept Chem, Rochester, NY USA
[6] Univ Sheffield, Sch Med, Mellanby Ctr Bone Res, Sheffield, S Yorkshire, England
[7] Univ Oxford, Inst Musculoskeletal Sci, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Botnar Res Ctr,Nuffield Orthopaed Ctr, Oxford, England
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2019年 / 85卷 / 06期
关键词：
Bisphosphonates; bone; osteoporosis; pharmacology; NITROGEN-CONTAINING BISPHOSPHONATES; BONE-MINERAL DENSITY; DISEASE SYSTEMS-ANALYSIS; RISEDRONATE; 35; MG; ZOLEDRONIC ACID; IN-VITRO; BREAST-CANCER; BIOCHEMICAL MARKERS; PAGETS-DISEASE; DRUG HOLIDAY;
D O I：
10.1111/bcp.13867
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Four decades of preclinical and clinical research of the pharmacology of bisphosphonates have generated data and concepts that have considerably improved their clinical use. However, despite this progress several pharmacological aspects relevant to bisphosphonate action on bone are still incompletely understood. This is mainly due to the complex, unique pharmacological properties of bisphosphonates. We review here the pharmacokinetic and pharmacodynamic data of bisphosphonates that are relevant for their clinical application and for the potential choice of a given compound, focusing on uncertainties that still exist. This article is part of a Special Issue entitled Bisphosphonates. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：1052 / 1062
页数：11
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