Randomized trial of weekly sulfadoxine/pyrimethamine vs. daily low-dose trimethoprim-sulfamethoxazole for the prophylaxis of Pneumocystis carinii pneumonia after liver transplantation

被引：28
作者：
Torre-Cisneros, J
De la Mata, M
Pozo, JC
Serrano, P
Briceño, J
Solórzano, G
Miño, G
Pera, C
Sánchez-Guijo, P
机构：
[1] Hosp Univ Reina Sofia, Infect Dis Sect, Cordoba, Spain
[2] Hosp Univ Reina Sofia, Liver Transplantat Unit, Cordoba, Spain
来源：
CLINICAL INFECTIOUS DISEASES | 1999年 / 29卷 / 04期
关键词：
D O I：
10.1086/520432
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We conducted a prospective, randomized clinical trial among liver transplant patients to assess the efficacy and safety of weekly sulfadoxine/pyrimethamine compared with daily trimethoprimsulfamethoxazole in the prevention of Pneumocystis carinii pneumonia, The studied drugs were given during 6 months after transplantation. One hundred twenty patients were included. None of the 60 patients receiving weekly sulfadoxine/pyrimethamine developed Pneumocystis carinii pneumonia, whereas two cases (3%) developed among the 60 patients who received trimethoprimsulfamethoxazole. For both patients, the studied medication had been discontinued several weeks earlier because of adverse effects. No differences were observed in the incidence of adverse effects. We conclude that weekly sulfadoxine/pyrimethamine is as effective and safe as is daily trimethoprim-sulfamethoxazole in the prophylaxis of Pneumocystis carinii pneumonia after liver transplantation.
引用
收藏
页码：771 / 774
页数：4
相关论文
共 22 条
[1]   Rejection treatment and cytomegalovirus infection as risk factors for Pneumocystis carinii pneumonia in renal transplant recipients [J].
Arend, SM ;
Westendorp, RGJ ;
Kroon, FP ;
vantWout, JW ;
Vandenbroucke, JP ;
vanEs, LA ;
vanderWoude, FJ .
CLINICAL INFECTIOUS DISEASES, 1996, 22 (06) :920-925
[2]   ADMINISTRATION OF PYRIMETHAMINE SULFADOXINE FOR PREVENTION OF PNEUMOCYSTIS-CARINII PNEUMONIA IN PATIENTS WITH AIDS [J].
BESSESEN, MT ;
MILLER, LA ;
COHN, DL ;
BARTLETT, S ;
ELLISON, RT .
CLINICAL INFECTIOUS DISEASES, 1995, 20 (03) :730-731
[3]  
*CDC, 1988, MMWR-MORBID MORTAL W, V37, P571
[4]   THE SPECTRUM OF PNEUMOCYSTIS-CARINII INFECTION AFTER LIVER-TRANSPLANTATION IN CHILDREN [J].
COLOMBO, JL ;
SAMMUT, PH ;
LANGNAS, AN ;
SHAW, BW .
TRANSPLANTATION, 1992, 54 (04) :621-624
[5]   FANSIDAR PROPHYLAXIS OF PNEUMOCYSTIS PNEUMONIA IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].
FISCHL, MA ;
DICKINSON, GM .
ANNALS OF INTERNAL MEDICINE, 1986, 105 (04) :629-629
[6]  
GOTTLIEB MS, 1984, LANCET, V2, P398
[7]  
HAYES MJ, 1994, CLIN TRANSPLANT, V8, P499
[8]  
HIGGINS RM, 1989, TRANSPLANTATION, V47, P558, DOI 10.1097/00007890-198903000-00032
[9]   SUCCESSFUL CHEMOPROPHYLAXIS FOR PNEUMOCYSTIS-CARINII PNEUMONITIS [J].
HUGHES, WT ;
KUHN, S ;
CHAUDHARY, S ;
FELDMAN, S ;
VERZOSA, M ;
AUR, RJA ;
PRATT, C ;
GEORGE, SL .
NEW ENGLAND JOURNAL OF MEDICINE, 1977, 297 (26) :1419-1426
[10]   SUCCESSFUL INTERMITTENT CHEMOPROPHYLAXIS FOR PNEUMOCYSTIS-CARINII PNEUMONITIS [J].
HUGHES, WT ;
RIVERA, GK ;
SCHELL, MJ ;
THORNTON, D ;
LOTT, L .
NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (26) :1627-1632
123