Enhanced antitumor immunity is elicited by adenovirus-mediated gene transfer of CCL21 and IL-15 in murine colon carcinomas

被引：24

作者：

Zhao, Dong-xu ^{[1
]}

Li, Zhi-jie ^{[2
]}

Zhang, Yang ^{[4
]}

Zhang, Xiao-na ^{[4
]}

Zhao, Kun-chi ^{[1
]}

Li, Ya-gang ^{[3
]}

Zhang, Meng-meng ^{[3
]}

Yu, Xiao-wei ^{[4
]}

Liu, Ming-yuan ^{[1
,5
]}

Li, Yang ^{[1
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Inst Zoonosis, Key Lab Zoonosis,Minist Educ, Changchun 130062, Peoples R China

[2] Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150001, Peoples R China

[3] Jilin Univ, Hosp 4, Changchun 130062, Peoples R China

[4] Jilin Univ, Hosp 1, Changchun 130021, Jilin Province, Peoples R China

[5] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2014年 / 289卷 / 1-2期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

CCL21; IL-15; Bicistronic adenovirus; Chemokines; Cancer immunotherapy; DENDRITIC CELLS; TUMOR-IMMUNOTHERAPY; TNF-ALPHA; CANCER; EXPRESSION; COMBINATION; CHEMOKINES; INFECTION; CYTOKINES; THERAPY;

D O I：

10.1016/j.cellimm.2014.03.020

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The chemokine CCL21 is a potent chemoattractant for T cells and dendritic cells. IL-15 elicits powerful antitumor immune responses through the stimulation of natural killer cells. We constructed a CCL21/ IL-15-expressing adenovirus (Ad-CCL21-IL-15) and evaluated its antitumor effects in vitro and in vivo. We found that the intratumoral injection of Ad-CCL21-IL-15 into murine colon carcinomas significantly inhibited tumor growth. Splenocytes from mice treated with Ad-CCL21-IL-15 developed tumor-specific cytotoxic T cells and were protected from subsequent challenges with tumor cells. This study indicates that providing cancer therapy by combining CCL21 and IL-15 can induce antitumor immune responses and is an effective strategy for cancer immunotherapy. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：155 / 161

页数：7

共 19 条

[1] Adenovirus-mediated CCL20/IL-15 gene transfer enhances antitumor immunity in mice
Liu, Guang-yao
Jia, Qiu-ying
Li, Zhi-jie
Li, Ya-gang
Zhang, Meng-meng
Liu, Ming-yuan
Wang, Xue-lin
Li, Yang
IMMUNOBIOLOGY, 2014, 219 (06) : 475 - 481
[2] Adenovirus-mediated gene transfer of macrophage inflammatory protein 3α to murine tumor induces antitumor immunity.
Fushimi, T
Kojima, A
Crystal, RG
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 159 (03) : A206 - A206
[3] Adenovirus-mediated interleukin 21 gene transfer enhances antitumor immunity and reduces tumorigenicity of Hepa1-6 in mice
Ju, Jiyu
Wang, Lina
Di, Dalin
Xiao, Weiling
Peng, Meiyu
Liu, Yishuai
Fu, Xiaoyan
Zhao, Chunling
Qin, Xuebin
ONCOLOGY LETTERS, 2016, 12 (05) : 3749 - 3754
[4] Interleukin (IL)-21 and IL-15 genetic transfer synergistically augments therapeutic antitumor immunity and promotes regression of metastatic lymphoma
Kishida, T
Asada, H
Itokawa, Y
Cui, FD
Shin-Ya, M
Gojo, S
Yasutomi, K
Ueda, Y
Yamagishi, H
Imanishi, J
Mazda, O
MOLECULAR THERAPY, 2003, 8 (04) : 552 - 558
[5] Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis
Apparailly, F
Verwaerde, C
Jacquet, C
Auriault, C
Sany, J
Jorgensen, C
JOURNAL OF IMMUNOLOGY, 1998, 160 (11): : 5213 - 5220
[6] Respective roles of TNF-α and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice
K Benihoud
S Esselin
D Descamps
B Jullienne
B Salone
P Bobé
D Bonardelle
E Connault
P Opolon
I Saggio
M Perricaudet
Gene Therapy, 2007, 14 : 533 - 544
[7] Respective roles of TNF-α and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice
Benihoud, K.
Esselin, S.
Descamps, D.
Jullienne, B.
Salone, B.
Bobe, P.
Bonardelle, D.
Connault, E.
Opolon, P.
Saggio, I.
Perricaudet, M.
GENE THERAPY, 2007, 14 (06) : 533 - 544
[8] Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma
D W Ju
Q Tao
D S Cheng
W Zhang
M Zhang
H Hamada
X Cao
Gene Therapy, 2000, 7 : 329 - 338
[9] Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma
Ju, DW
Tao, Q
Cheng, DS
Zhang, W
Zhang, M
Hamada, H
Cao, X
GENE THERAPY, 2000, 7 (04) : 329 - 338
[10] Erratum: Respective roles of TNF-α and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice
K Benihoud
S Esselin
D Descamps
B Jullienne
B Salone
P Bobé
D Bonardelle
E Connault
P Opolon
I Saggio
M Perricaudet
Gene Therapy, 2007, 14 : 551 - 551

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