Toxin-resolved antivenomics-guided assessment of the immunorecognition landscape of antivenoms

被引:43
作者
Calvete, Juan J. [1 ]
Rodriguez, Yania [1 ]
Quesada-Bernat, Sarai [1 ]
Pla, Davinia [1 ]
机构
[1] CSIC, Evolutionary & Translat Ven Lab, Valencia, Spain
基金
英国医学研究理事会;
关键词
Neglected tropical disease; Snakebite envenoming; Snake antivenom; Snake venomics; Third-generation antivenomics; PAPUA-NEW-GUINEA; GLAND TRANSCRIPTOME ANALYSIS; SUB-SAHARAN AFRICA; TOP-DOWN VENOMICS; ECHITAB-PLUS-ICP; SNAKE VENOMICS; POLYSPECIFIC ANTIVENOM; PRECLINICAL EFFICACY; CROSS-NEUTRALIZATION; SRI-LANKA;
D O I
10.1016/j.toxicon.2018.04.015
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Snakebite envenoming represents a major issue in rural areas of tropical and subtropical regions across sub-Saharan Africa, South to Southeast Asia, Latin America and Oceania. Antivenoms constitute the only scientifically validated therapy for snakebite envenomings, provided they are safe, effective, affordable, accessible and administered appropriately. However, the lack of financial incentives in a technology that has remained relatively unchanged for more than a century, has contributed to some manufacturers leaving the market and others downscaling production or increasing the prices, leading to a decline in the availability and accessibility for these life-saving antidotes to millions of rural poor most at risk from snakebites in low income countries. The shortage of antivenoms can be significantly alleviated by optimizing the use of current antivenoms (through the assessment of their specific and paraspecific efficacy against the different medically relevant homologous and heterologous snake venoms) and by generating novel polyspecific antivenoms exhibiting broad clinical spectrum and wide geographic distribution range. Research on venoms has been continuously enhanced by advances in technology. Particularly, the last decade has witnessed the development of omics strategies for unravelling the toxin composition of venoms ("venomics") and to assess the immunorecognition profile of antivenoms ("antivenomics"). Here, we review recent developments and reflect on near future innovations that promise to revolutionize the mutually enlightening relationship between evolutionary and translational venomics. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码:107 / 122
页数:16
相关论文
共 142 条
  • [21] Next-generation snake venomics: protein-locus resolution through venom proteome decomplexation
    Calvete, Juan J.
    [J]. EXPERT REVIEW OF PROTEOMICS, 2014, 11 (03) : 315 - 329
  • [22] Calvete JJ, 2011, EXPERT REV PROTEOMIC, V8, P739, DOI [10.1586/EPR.11.61, 10.1586/epr.11.61]
  • [23] Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management
    Calvete, Juan J.
    Sanz, Libia
    Perez, Alicia
    Borges, Adolfo
    Vargas, Alba M.
    Lomonte, Bruno
    Angulo, Yamileth
    Maria Gutierrez, Jose
    Chalkidis, Hipocrates M.
    Mourao, Rosa H. V.
    Furtado, M. Fatima D.
    Moura-Da-Silva, Ana M.
    [J]. JOURNAL OF PROTEOMICS, 2011, 74 (04) : 510 - 527
  • [24] Antivenomic Assessment of the Immunological Reactivity of EchiTAb-Plus-ICP, an Antivenom for the Treatment of Snakebite Envenoming in Sub-Saharan Africa
    Calvete, Juan J.
    Cid, Pedro
    Sanz, Libia
    Segura, Alvaro
    Villalta, Mauren
    Herrera, Maria
    Leon, Guillermo
    Harrison, Robert
    Durfa, Nandul
    Nasidi, Abdusalami
    Theakston, R. David G.
    Warrell, David A.
    Maria Gutierrez, Jose
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2010, 82 (06) : 1194 - 1201
  • [25] Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic Trend along Crotalus Dispersal in South America
    Calvete, Juan J.
    Sanz, Libia
    Cid, Pedro
    de la Torre, Pillar
    Flores-Diaz, Marietta
    Cristina Dos Santos, M.
    Borges, Adolfo
    Bremo, Adolfo
    Angulo, Yamileth
    Lomonte, Bruno
    Alape-Giron, Alberto
    Maria Gutierrez, Jose
    [J]. JOURNAL OF PROTEOME RESEARCH, 2010, 9 (01) : 528 - 544
  • [26] Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management
    Calvete, Juan J.
    Borges, Adolfo
    Segura, Alvaro
    Flores-Diaz, Marietta
    Alape-Giron, Alberto
    Gutierrez, Jose Maria
    Diez, Nardy
    De Sousa, Leonardo
    Kiriakos, Demetrio
    Sanchez, Eladio
    Faks, Jose G.
    Escolano, Jose
    Sanz, Libia
    [J]. JOURNAL OF PROTEOMICS, 2009, 72 (02) : 227 - 240
  • [27] Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms
    Casewell, Nicholas R.
    Wagstaff, Simon C.
    Wuester, Wolfgang
    Cook, Darren A. N.
    Bolton, Fiona M. S.
    King, Sarah I.
    Pla, Davinia
    Sanz, Libia
    Calvete, Juan J.
    Harrison, Robert A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (25) : 9205 - 9210
  • [28] Snakebite envenomation turns again into a neglected tropical disease!
    Chippaux, Jean-Philippe
    [J]. JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, 2017, 23
  • [29] Significance Analysis of Spectral Count Data in Label-free Shotgun Proteomics
    Choi, Hyungwon
    Fermin, Damian
    Nesvizhskii, Alexey I.
    [J]. MOLECULAR & CELLULAR PROTEOMICS, 2008, 7 (12) : 2373 - 2385
  • [30] Unusual Stability of Messenger RNA in Snake Venom Reveals Gene Expression Dynamics of Venom Replenishment
    Currier, Rachel B.
    Calvete, Juan J.
    Sanz, Libia
    Harrison, Robert A.
    Rowley, Paul D.
    Wagstaff, Simon C.
    [J]. PLOS ONE, 2012, 7 (08):