β-defensins:: Linking innate and adaptive immunity through dendritic and T cell CCR6

被引:1464
作者
Yang, D
Chertov, O
Bykovskaia, N
Chen, Q
Buffo, MJ
Shogan, J
Anderson, M
Schröder, JM
Wang, JM
Howard, OMZ
Oppenheim, JJ [1 ]
机构
[1] NCI, Mol Immunoregulat Lab, Div Basic Sci, SAIC Frederick,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
[2] NCI, Intramural Res Support Program, SAIC Frederick, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
[3] Allegheny Univ Hlth Sci, Pittsburgh, PA 15212 USA
[4] Magainin Res Inst, Plymouth Meeting, PA 19642 USA
[5] Univ Kiel, Dept Dermatol, D-24105 Kiel, Germany
关键词
D O I
10.1126/science.286.5439.525
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine Ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.
引用
收藏
页码:525 / 528
页数:4
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