LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures

被引：208

作者：

Duan, Qiaonan ^{[1
]}

Flynn, Corey ^{[2
]}

Niepel, Mario ^{[3
]}

Hafner, Marc ^{[3
]}

Muhlich, Jeremy L. ^{[3
]}

Fernandez, Nicolas F. ^{[1
]}

Rouillard, Andrew D. ^{[1
]}

Tan, Christopher M. ^{[1
]}

Chen, Edward Y. ^{[1
]}

Golub, Todd R. ^{[2
]}

Sorger, Peter K. ^{[3
]}

Subramanian, Aravind ^{[2
]}

Ma'ayan, Avi ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, SBCNY, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

[2] Broad Inst, Cambridge, MA 02142 USA

[3] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / W1期

关键词：

SET ENRICHMENT ANALYSIS; CONNECTIVITY MAP; INTERLEUKIN-1; TOOL; PROLIFERATION; VISUALIZATION; ENCYCLOPEDIA; INHIBITOR; DATABASE;

D O I：

10.1093/nar/gku476

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For the Library of Integrated Network-based Cellular Signatures (LINCS) project many gene expression signatures using the L1000 technology have been produced. The L1000 technology is a cost-effective method to profile gene expression in large scale. LINCS Canvas Browser (LCB) is an interactive HTML5 web-based software application that facilitates querying, browsing and interrogating many of the currently available LINCS L1000 data. LCB implements two compacted layered canvases, one to visualize clustered L1000 expression data, and the other to display enrichment analysis results using 30 different gene set libraries. Clicking on an experimental condition highlights gene-sets enriched for the differentially expressed genes from the selected experiment. A search interface allows users to input gene lists and query them against over 100 000 conditions to find the top matching experiments. The tool integrates many resources for an unprecedented potential for new discoveries in systems biology and systems pharmacology.

引用

页码：W449 / W460

页数：12

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