Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits

被引：23

作者：

Ahn, Chan Mug ^{[2
]}

Park, Byong-Gon ^{[3
]}

Woo, Ho Bum ^{[2
]}

Ham, Jungyeob ^{[4
]}

Shin, Woon-Seob ^{[1
]}

Lee, Seokjoon ^{[5
]}

机构：

[1] Kwandong Univ, Coll Med, Dept Microbiol, Kangnung 210701, South Korea

[2] Yonsei Univ, Wonju Coll Med, Dept Basic Sci, Wonju 220701, South Korea

[3] Kwandong Univ, Coll Med, Dept Physiol, Kangnung 210701, South Korea

[4] Gangneung Inst, Korea Inst Sci & Technol, Kangnung 210340, South Korea

[5] Kwandong Univ, Coll Med, Dept Basic Sci, Kangnung 210701, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 05期

关键词：

Organic synthesis; Curcumin; Sulfonyl curcumin mimics; Vasodilatation; Basilar artery; ENDOTHELIN-1-INDUCED CONTRACTION; MULTIDRUG-RESISTANCE; RAT AORTA; EFFICACY; REVERSAL; SAFETY;

D O I：

10.1016/j.bmcl.2009.01.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

引用

页码：1481 / 1483

页数：3

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