Synthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages

被引：75

作者：

Fukushima, Naoki ^{[1
]}

Ieda, Naoya ^{[1
]}

Sasakura, Kiyoshi ^{[2
]}

Nagano, Tetsuo ^{[2
]}

Hanaoka, Kenjiro ^{[2
]}

Suzuki, Takayoshi ^{[3
]}

Miyata, Naoki ^{[1
]}

Nakagawa, Hidehiko ^{[1
,4
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Kita Ku, Kyoto 6038334, Japan

[4] Japan Sci & Technol Agcy JST, PRESTO, Kawaguchi, Saitama 3320012, Japan

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

H2S; VASORELAXANT; ATP;

D O I：

10.1039/c3cc47421f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the design, synthesis and application of a directly photocontrollable hydrogen sulfide (H2S) donor, which releases H2S proportionally to the intensity and duration of photoirradiation. Photocontrolled H2S release from this donor was also demonstrated in bovine serum. This H2S donor should be suitable for use in various biological systems.

引用

页码：587 / 589

页数：3

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