Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria

被引：41

作者：

Giannangelo, Carlo ^{[1
]}

Fowkes, Freya J. I. ^{[2
,3
,4
]}

Simpson, Julie A. ^{[3
]}

Charman, Susan A. ^{[5
]}

Creek, Darren J. ^{[1
]}

机构：

[1] Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Clayton, Vic, Australia

[2] Burnet Inst, Melbourne, Vic, Australia

[3] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia

[4] Monash Univ, Dept Epidemiol & Prevent Med, Clayton, Vic, Australia

[5] Monash Univ, Monash Inst Pharmaceut Sci, Ctr Drug Candidate Optimisat, Clayton, Vic, Australia

来源：

TRENDS IN PARASITOLOGY | 2019年 / 35卷 / 07期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

PLASMODIUM-FALCIPARUM MALARIA; IN-VITRO ASSESSMENT; DELAYED-CLEARANCE; PHARMACODYNAMIC PROPERTIES; SYNTHETIC TRIOXOLANE; HEME ALKYLATION; RING STAGES; DIHYDROARTEMISININ; ARTESUNATE; ARTEROLANE;

D O I：

10.1016/j.pt.2019.05.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The ozonides are one of the most advanced drug classes in the antimalarial development pipeline and were designed to improve on limitations associated with current front-line artemisinin-based therapies. Like the artemisinins, the pharmacophoric peroxide bond of ozonides is essential for activity, and it appears that these antimalarials share a similar mode of action, raising the possibility of cross-resistance. Resistance to artemisinins is associated with Plasmodium falciparum mutations that allow resistant parasites to escape short-term artemisinin-mediated damage (elimination half-life similar to 1 h). Importantly, some ozonides (e.g., OZ439) have a sustained in vivo drug exposure profile, providing a major pharmacokinetic advantage over the artemisinin derivatives. Here, we describe recent progress made towards understanding ozonide antimalarial activity and discuss ozonide utility within the context of artemisinin resistance.

引用

页码：529 / 543

页数：15

共 112 条

[1] Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways [J].

Allman, Erik L. ;

Painter, Heather J. ;

Samra, Jasmeet ;

Carrasquilla, Manuela ;

Llinas, Manuel .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (11) :6635-6649

[2] Plasmodium falciparum Founder Populations in Western Cambodia Have Reduced Artemisinin Sensitivity In Vitro [J].

Amaratunga, Chanaki ;

Witkowski, Benoit ;

Dek, Dalin ;

Try, Vorleak ;

Khim, Nimol ;

Miotto, Olivo ;

Menard, Didier ;

Fairhurst, Rick M. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (08) :4935-4937

[3]

[Anonymous], 2018, World Drug Report 2018

[4]

[Anonymous], 2018, ART RES ART BAS COMB

[5] A molecular marker of artemisinin-resistant Plasmodium falciparum malaria [J].

Ariey, Frederic ;

Witkowski, Benoit ;

Amaratunga, Chanaki ;

Beghain, Johann ;

Langlois, Anne-Claire ;

Khim, Nimol ;

Kim, Saorin ;

Duru, Valentine ;

Bouchier, Christiane ;

Ma, Laurence ;

Lim, Pharath ;

Leang, Rithea ;

Duong, Socheat ;

Sreng, Sokunthea ;

Suon, Seila ;

Chuor, Char Meng ;

Bout, Denis Mey ;

Menard, Sandie ;

Rogers, William O. ;

Genton, Blaise ;

Fandeur, Thierry ;

Miotto, Olivo ;

Ringwald, Pascal ;

Le Bras, Jacques ;

Berry, Antoine ;

Barale, Jean-Christophe ;

Fairhurst, Rick M. ;

Benoit-Vical, Franoise ;

Mercereau-Puijalon, Odile ;

Menard, Didier .

NATURE, 2014, 505 (7481) :50-+

[6] Spread of Artemisinin Resistance in Plasmodium falciparum Malaria [J].

Ashley, E. A. ;

Dhorda, M. ;

Fairhurst, R. M. ;

Amaratunga, C. ;

Lim, P. ;

Suon, S. ;

Sreng, S. ;

Anderson, J. M. ;

Mao, S. ;

Sam, B. ;

Sopha, C. ;

Chuor, C. M. ;

Nguon, C. ;

Sovannaroth, S. ;

Pukrittayakamee, S. ;

Jittamala, P. ;

Chotivanich, K. ;

Chutasmit, K. ;

Suchatsoonthorn, C. ;

Runcharoen, R. ;

Hien, T. T. ;

Thuy-Nhien, N. T. ;

Thanh, N. V. ;

Phu, N. H. ;

Htut, Y. ;

Han, K-T. ;

Aye, K. H. ;

Mokuolu, O. A. ;

Olaosebikan, R. R. ;

Folaranmi, O. O. ;

Mayxay, M. ;

Khanthavong, M. ;

Hongvanthong, B. ;

Newton, P. N. ;

Onyamboko, M. A. ;

Fanello, C. I. ;

Tshefu, A. K. ;

Mishra, N. ;

Valecha, N. ;

Phyo, A. P. ;

Nosten, F. ;

Yi, P. ;

Tripura, R. ;

Borrmann, S. ;

Bashraheil, M. ;

Peshu, J. ;

Faiz, M. A. ;

Ghose, A. ;

Hossain, M. A. ;

Samad, R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (05) :411-423

[7] Declining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study [J].

Ataide, Ricardo ;

Powell, Rosanna ;

Moore, Kerryn ;

McLean, Alistair ;

Phyo, Aung Pyae ;

Nair, Shalini ;

White, Marina ;

Anderson, Tim J. ;

Beeson, James G. ;

Simpson, Julie A. ;

Nosten, Francois ;

Fowkes, Freya J. I. .

JOURNAL OF INFECTIOUS DISEASES, 2017, 216 (06) :723-731

[8] Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort [J].

Ataide, Ricardo ;

Ashley, Elizabeth A. ;

Powell, Rosanna ;

Chan, Jo-Anne ;

Malloy, Michael J. ;

O'Flaherty, Katherine ;

Takashima, Eizo ;

Langer, Christine ;

Tsuboi, Takafumi ;

Dondorp, Arjen M. ;

Day, Nicholas P. ;

Dhorda, Mehul ;

Fairhurst, Rick M. ;

Lim, Pharath ;

Amaratunga, Chanaki ;

Pukrittayakamee, Sasithon ;

Tran Tinh Hien ;

Htut, Ye ;

Mayxay, Mayfong ;

Abul Faiz, M. ;

Beeson, James G. ;

Nosten, Francois ;

Simpson, Julie A. ;

White, Nicholas J. ;

Fowkes, Freya J. I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (13) :3515-3520

[9] In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border [J].

Barends, Marion ;

Jaidee, Anchalee ;

Khaohirun, Nopparat ;

Singhasivanon, Pratap ;

Nosten, Francois .

MALARIA JOURNAL, 2007, 6 (1)

[10] In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate [J].

Baumgartner, Fabian ;

Jourdan, Joelle ;

Scheurer, Christian ;

Blasco, Benjamin ;

Campo, Brice ;

Maser, Pascal ;

Wittlin, Sergio .

MALARIA JOURNAL, 2017, 16

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