Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

被引：1112

作者：

Blackburn, Elizabeth H. ^{[1
]}

Epel, Elissa S. ^{[2
]}

Lin, Jue ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

来源：

SCIENCE | 2015年 / 350卷 / 6265期

关键词：

DNA-DAMAGE; LENGTH; ASSOCIATION; STRESS; CANCER; DYSFUNCTION; WERNER; LIFE; HEALTH; PATHOGENESIS;

D O I：

10.1126/science.aab3389

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes. Telomere attrition can lead to potentially maladaptive cellular changes, block cell division, and interfere with tissue replenishment. Recent advances in the understanding of human disease processes have clarified the roles of telomere biology, especially in diseases of human aging and in some aging-related processes. Greater overall telomere attrition predicts mortality and aging-related diseases in inherited telomere syndrome patients, and also in general human cohorts. However, genetically caused variations in telomere maintenance either raise or lower risks and progression of cancers, in a highly cancer type-specific fashion. Telomere maintenance is determined by genetic factors and is also cumulatively shaped by nongenetic influences throughout human life; both can interact. These and other recent findings highlight both causal and potentiating roles for telomere attrition in human diseases.

引用

页码：1193 / 1198

页数：6

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