Aerosolized liposomes with dipalmitoyl phosphatidylcholine enhance pulmonary insulin delivery

被引：79

作者：

Chono, Sumio ^{[1
]}

Fukuchi, Rie ^{[1
]}

Seki, Toshinobu ^{[1
]}

Morimoto, Kazuhiro ^{[1
]}

机构：

[1] Hokkaido Pharmaceut Univ, Grad Sch Pharmaceut Sci, Dept Pharmaceut, Otaru, Hokkaido 0470264, Japan

来源：

JOURNAL OF CONTROLLED RELEASE | 2009年 / 137卷 / 02期

关键词：

Liposomes; Dipalmitoyl phosphatidylcholine; Pulmonary delivery; Insulin; Lung surfactant components; RAT ALVEOLAR MACROPHAGES; ABSORPTION ENHANCERS; SALMON-CALCITONIN; DRUG-DELIVERY; PARTICLE-SIZE; RELEASE;

D O I：

10.1016/j.jconrel.2009.03.019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pulmonary insulin delivery characteristics of liposomes were examined. Aerosolized liposomes containing insulin were administered into rat lungs and the enhancing effect on insulin delivery was evaluated by changes of plasma glucose levels. Liposomes with dipalmitoyl phosphatidylcholine (DPPC) enhanced pulmonary insulin delivery in rats, however, liposomes with dilauroyl, dimyristoyl, distearoyl or dioleoyl phosphatidylcholine did not. Liposomes with DPPC also enhanced the in vitro permeation of FITC dextran (Mw 4400, FD-4) through the calu-3 cell monolayer by reducing the transepithelial electrical resistance and did not harm lung tissues in rats. These findings suggest that liposomes with DPPC enhance pulmonary insulin delivery by opening the epithelial cell space in the pulmonary mucosa not mucosal cell damage. Liposomes with DPPC could be useful as a pulmonary delivery system for peptide and protein drugs. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：104 / 109

页数：6

共 27 条

[1] ACCUMULATION OF AMIODARONE AND DESETHYLAMIODARONE BY RAT ALVEOLAR MACROPHAGES IN CELL-CULTURE [J].