Emergent dynamics of cardiomyocyte clusters on deformable polymeric substrates

被引：4

作者：

Anand, Sandeep V. ^{[1
]}

Saif, Taher A. ^{[1
]}

机构：

[1] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA

来源：

EXTREME MECHANICS LETTERS | 2016年 / 8卷

基金：

美国国家科学基金会;

关键词：

Cardiomyocyte; Force dipole; Thin films; Mechanosensitive; Dynamics; Compliance; CARDIAC MYOCYTES; BIOLOGICAL MACHINES; FOCAL ADHESION; STIFFNESS; FORCE; CELLS;

D O I：

10.1016/j.eml.2015.09.008

中图分类号：

TH [机械、仪表工业];

学科分类号：

0802 ;

摘要：

Contractile dynamics of primary cardiomyocyte clusters is studied by culturing them on deformable thin polymeric films. The cell clusters beat and generate sufficient forces to deform the substrates out of plane. Over time, the clusters reorient their force dipoles along the direction of maximum compliance. This suggests that the cells are capable of sensing substrate deformations through a mechanosensitive feedback mechanism and dynamically reorganizing themselves. (C) 2016 Published by Elsevier Ltd.

引用

页码：1 / 5

页数：5

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