Involvement of leukotriene B4 in dermatophyte-related itch in mice

被引：12
作者：
Andoh, Tsugunobu [1 ]
Takayama, Yusuke [1 ]
Kuraishi, Yasushi [1 ]
机构：
[1] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Dept Appl Pharmacol, Sugitani, Toyama, Japan
来源：
PHARMACOLOGICAL REPORTS | 2014年 / 66卷 / 04期
关键词：
Dermatophyte; Itch; Leukotriene B-4; 5-Lipoxygenase; Proteinase-activated receptor 2; RESPONSES; RECEPTOR; METABOLISM; PAIN;
D O I：
10.1016/j.pharep.2014.01.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: Proteinase-activated receptor-2 (PAR(2)) is involved in dermatophyte-induced scratching and leukotriene B-4 (LTB4) release from keratinocytes. We investigated whether PAR(2)-mediated LTB4 production is involved in dermatophyte-induced scratching. Methods: Dermatophyte extract was injected intradermally and scratching was observed in mice. LTB4 was determined by enzyme immunoassay. Results: Dermatophyte extract-induced scratching was inhibited by zileuton (5-lipoxygenase inhibitor), ONO-4057 (LTB4 antagonist), FSLLRY-NH2 (PAR(2) antagonist), and anti-PAR(2) antibody. Dermatophyte extract injection increased the cutaneous content of LTB4, which was inhibited by zileuton and FSLLRY-NH2. Conclusion: These results suggest the involvement of LTB4 in dermatophyte-associated itch. LTB4 production might be due to PAR(2) stimulation in the skin. (C) 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
引用
收藏
页码：699 / 703
页数：5
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