Cell penetrating peptides: Efficient vectors for delivery of nanoparticles, nanocarriers, therapeutic and diagnostic molecules

被引：217

作者：

Farkhani, Samad Mussa ^{[1
,5
]}

Valizadeh, Alireza ^{[1
]}

Karami, Hadi ^{[2
]}

Mohammadi, Samane ^{[1
]}

Sohrabi, Nasrin ^{[3
]}

Badrzadeh, Fariba ^{[4
]}

机构：

[1] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Nanotechnol, Tabriz 51664, Iran

[2] Arak Univ Med Sci, Dept Med Biotechnol, Fac Med, Sardasht 38481, Arak, Iran

[3] Tabriz Univ Med Sci, Dept Med Genet, Fac Med, Tabriz 51664, Iran

[4] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Biotechnol, Tabriz 51664, Iran

[5] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz 51664, Iran

来源：

PEPTIDES | 2014年 / 57卷

关键词：

Cell penetrating peptides; Drug delivery; Endosomal escape; Nanocarrier; Nanoparticle; Gene delivery; BLOOD-BRAIN-BARRIER; ARGININE-RICH PEPTIDES; PEG-PLA NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; OVERCOMING MULTIDRUG-RESISTANCE; ANTICANCER DRUG-DELIVERY; IRON-OXIDE NANOPARTICLES; CONJUGATED QUANTUM DOTS; MESENCHYMAL STEM-CELLS; TAT-PEPTIDE;

D O I：

10.1016/j.peptides.2014.04.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Efficient delivery of therapeutic and diagnostic molecules to the cells and tissues is a difficult challenge. The cellular membrane is very effective in its role as a selectively permeable barrier. While it is essential for cell survival and function, also presents a major barrier for intracellular delivery of cargo such as therapeutic and diagnostic agents. In recent years, cell-penetrating peptides (CPPs), that are relatively short cationic and/or amphipathic peptides, received great attention as efficient cellular delivery vectors due to their intrinsic ability to enter cells and mediate uptake of a wide range of macromolecular cargo such as plasmid DNA (pDNA), small interfering RNA (siRNAs), drugs, and nanoparticulate pharmaceutical carriers. This review discusses the various uptake mechanisms of these peptides. Furthermore, we discuss recent advances in the use of CPP for the efficient delivery of nanoparticles, nanocarriers, DNA, siRNA, and anticancer drugs to the cells. In addition, we have been highlighting new results for improving endosomal escape of CPP-cargo molecules. Finally, pH-responsive and activable CPPs for tumor-targeting therapy have been described. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：78 / 94

页数：17

共 201 条

[1] Vectorization of morpholino oligomers by the (R-Ahx-R)4 peptide allows efficient splicing correction in the absence of endosomolytic agents [J].

Abes, Said ;

Moulton, Hong M. ;

Clair, Philippe ;

Prevot, Paul ;

Youngblood, Derek S. ;

Wu, Rebecca P. ;

Iversen, Patrick L. ;

Lebleu, Bernard .

JOURNAL OF CONTROLLED RELEASE, 2006, 116 (03) :304-313

[2] Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides [J].

Aguilera, Todd A. ;

Olson, Emilia S. ;

Timmers, Margaret M. ;

Jiang, Tao ;

Tsien, Roger Y. .

INTEGRATIVE BIOLOGY, 2009, 1 (5-6) :371-381

[3] Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation [J].

Akita, Hidetaka ;

Kogure, Kentaro ;

Moriguchi, Rumiko ;

Nakamura, Yoshio ;

Higashi, Tomoko ;

Nakamura, Takashi ;

Serada, Satoshi ;

Fujimoto, Minoru ;

Naka, Tetsuji ;

Futaki, Shiroh ;

Harashima, Hideyoshi .

JOURNAL OF CONTROLLED RELEASE, 2010, 143 (03) :311-317

[4] Stimulated endocytosis in penetratin uptake:: Effect of arginine and lysine [J].

Amand, Helene L. ;

Fant, Kristina ;

Norden, Bengt ;

Esbjorner, Elin K. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 371 (04) :621-625

[5] Cell surface binding and uptake of arginine- and lysine-rich penetratin peptides in absence and presence of proteoglycans [J].

Amand, Helene L. ;

Rydberg, Hanna A. ;

Fornander, Louise H. ;

Lincoln, Per ;

Norden, Bengt ;

Esbjorner, Elin K. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2012, 1818 (11) :2669-2678

[6] Doxorubicin coupled to penetratin promotes apoptosis in CHO cells by a mechanism involving c-Jun NH2-terminal kinase [J].

Aroui, Sonia ;

Mili, Donia ;

Brahim, Souhir ;

De Waard, Michel ;

Kenani, Abderraouf .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 396 (04) :908-914

[7] Cytotoxicity, intracellular distribution and uptake of doxorubicin and doxorubicin coupled to cell-penetrating peptides in different cell lines: A comparative study [J].

Aroui, Sonia ;

Brahim, Souhir ;

De Waard, Michel ;

Kenani, Abderraouf .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 391 (01) :419-425

[8] Efficient induction of apoptosis by doxorubicin coupled to cell-penetrating peptides compared to unconjugated doxorubicin in the human breast cancer cell line MDA-MB 231 [J].

Aroui, Sonia ;

Brahim, Souhir ;

De Waard, Michel ;

Breard, Jacqueline ;

Kenani, Abderraouf .

CANCER LETTERS, 2009, 285 (01) :28-38

[9] Comparison of penetratin and other homeodomain-derived cell-penetrating peptides: Interaction in a membrane-mimicking environment and cellular uptake efficiency [J].

Balayssac, S ;

Burlina, F ;

Convert, O ;

Bolbach, G ;

Chassaing, G ;

Lequin, O .

BIOCHEMISTRY, 2006, 45 (05) :1408-1420

[10] Principles of strategic drug delivery to the brain (SDDB): Development of anorectic and orexigenic analogs of leptin [J].

Banks, W. A. ;

Gertler, A. ;

Solomon, G. ;

Niv-Spector, L. ;

Shpilman, M. ;

Yi, X. ;

Batrakova, E. ;

Vinogradov, S. ;

Kabanov, A. V. .

PHYSIOLOGY & BEHAVIOR, 2011, 105 (01) :145-149

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