Role of RASA1 in cancer: A review and update

被引：39
作者：
Zhang, Yanhua [1 ]
Li, Yue [1 ]
Wang, Quanyue [2 ]
Su, Bo [3 ,4 ]
Xu, Hui [1 ]
Sun, Yang [1 ]
Sun, Pei [3 ]
Li, Rumeng [3 ]
Peng, Xiaochun [3 ,5 ]
Cai, Jun [1 ]
机构：
[1] Yangtze Univ, Dept Oncol, Affiliated Hosp 1, 1 Nanhuan Rd, Jingzhou 434023, Hubei, Peoples R China
[2] Qinghai Inst Hlth Sci, Xining 810000, Qinghai, Peoples R China
[3] Yangtze Univ, Ctr Mol Med, Lab Oncol, Jingzhou 434023, Hubei, Peoples R China
[4] Yangtze Univ, Hlth Sci Ctr, Sch Basic Med, Dept Pathol, Jingzhou 434023, Hubei, Peoples R China
[5] Yangtze Univ, Hlth Sci Ctr, Sch Basic Med, Dept Pathophysiol, 1 Nanhuan Rd, Jingzhou 434023, Hubei, Peoples R China
来源：
ONCOLOGY REPORTS | 2020年 / 44卷 / 06期
关键词：
tumour; Ras p21 protein activator 1; microRNA; Ras; therapy; SQUAMOUS-CELL CARCINOMA; GTPASE-ACTIVATING PROTEIN-1; LUNG-CANCER; CAPILLARY MALFORMATION; MESSENGER-RNA; BREAST-CANCER; NEURONAL APOPTOSIS; COLORECTAL-CANCER; REGULATES RASA1; TARGETING RASA1;
D O I：
10.3892/or.2020.7807
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. As a result, RASA1 also contributes to pathological processes in vascular diseases and tumour formation. This review focuses on the role of RASA1 in multiple tumours types in the lung, intestines, liver, and breast. Furthermore, we discuss the potential mechanisms of RASA1 and its downstream effects through Ras/RAF/MEK/ERK or Ras/PI3K/AKT signalling. Moreover, miRNAs are capable of regulating RASA1 and could be a novel targeted treatment strategy for tumours.
引用
收藏
页码：2386 / 2396
页数：11
相关论文
共 127 条
  • [1] Germline Loss-of-Function Mutations in EPHB4 Cause a Second Form of Capillary Malformation-Arteriovenous Malformation (CM-AVM2) Deregulating RAS-MAPK Signaling
    Amyere, Mustapha
    Revencu, Nicole
    Helaers, Raphael
    Pairet, Eleonore
    Baselga, Eulalia
    Cordisco, Maria
    Chung, Wendy
    Dubois, Josee
    Lacour, Jean-Philippe
    Martorell, Loreto
    Mazereeuw-Hautier, Juliette
    Pyeritz, Reed E.
    Amor, David J.
    Bisdorff, Annouk
    Blei, Francine
    Bombei, Hannah
    Dompmartin, Anne
    Brooks, David
    Dupont, Juliette
    Gonzalez-Enseat, Maria Antonia
    Frieden, Ilona
    Gerard, Marion
    Kvarnung, Malin
    Hanson-Kahn, Andrea Kwan
    Hudgins, Louanne
    Leaute-Labreze, Christine
    McCuaig, Catherine
    Metry, Denise
    Parent, Philippe
    Paul, Carle
    Petit, Florence
    Phan, Alice
    Quere, Isabelle
    Salhi, Aicha
    Turner, Anne
    Vabres, Pierre
    Vicente, Asuncion
    Wargon, Orli
    Watanabe, Shoji
    Weibel, Lisa
    Wilson, Ashley
    Willing, Marcia
    Mulliken, John B.
    Boon, Laurence M.
    Vikkula, Miikka
    [J]. CIRCULATION, 2017, 136 (11) : 1037 - +
  • [2] MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis
    Anand, Sudarshan
    Majeti, Bharat K.
    Acevedo, Lisette M.
    Murphy, Eric A.
    Mukthavaram, Rajesh
    Scheppke, Lea
    Huang, Miller
    Shields, David J.
    Lindquist, Jeffrey N.
    Lapinski, Philip E.
    King, Philip D.
    Weis, Sara M.
    Cheresh, David A.
    [J]. NATURE MEDICINE, 2010, 16 (08) : 909 - U109
  • [3] [Anonymous], 2015, NAT COMMUN
  • [4] p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance
    Antoine-Bertrand, Judith
    Duquette, Philippe M.
    Alchini, Ricardo
    Kennedy, Timothy E.
    Fournier, Alyson E.
    Lamarche-Vane, Nathalie
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (09) : 4589 - 4602
  • [5] Lung Cancer 2020 Epidemiology, Etiology, and Prevention
    Bade, Brett C.
    Dela Cruz, Charles S.
    [J]. CLINICS IN CHEST MEDICINE, 2020, 41 (01) : 1 - +
  • [6] Silencing of microRNA-132 reduces renal fibrosis by selectively inhibiting myofibroblast proliferation
    Bijkerk, Roel
    de Bruin, Ruben G.
    van Solingen, Coen
    van Gils, Janine M.
    Duijs, Jacques M. G. J.
    van der Veer, Eric P.
    Rabelink, Ton J.
    Humphreys, Benjamin D.
    van Zonneveld, Anton Jan
    [J]. KIDNEY INTERNATIONAL, 2016, 89 (06) : 1268 - 1280
  • [7] Multiple cerebral and spinal cord cavernomas in Klippel-Trenaunay-Weber syndrome
    Boutarbouch, Mahjouba
    Ben Salem, Douraied
    Gire, Laurent
    Giroud, Maurice
    Bejot, Yannick
    Ricolfi, Frederic
    [J]. JOURNAL OF CLINICAL NEUROSCIENCE, 2010, 17 (08) : 1073 - 1075
  • [8] Differentially Tolerized Mouse Antigen Presenting Cells Share a Common miRNA Signature Including Enhanced mmu-miR-223-3p Expression Which Is Sufficient to Imprint a Protolerogenic State
    Bros, Matthias
    Youns, Mahmoud
    Kollek, Verena
    Buchmueller, Diana
    Bollmann, Franziska
    Seo, Ean-Jeong
    Schupp, Jonathan
    Montermann, Evelyn
    Usanova, Svetlana
    Kleinert, Hartmut
    Efferth, Thomas
    Reske-Kunz, Angelika B.
    [J]. FRONTIERS IN PHARMACOLOGY, 2018, 9
  • [9] Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man
    Burrows, Patricia E.
    Gonzalez-Garay, Manuel L.
    Rasmussen, John C.
    Aldrich, Melissa B.
    Guilliod, Renie
    Maus, Erik A.
    Fife, Caroline E.
    Kwon, Sunkuk
    Lapinski, Philip E.
    King, Philip D.
    Sevick-Muraca, Eva M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (21) : 8621 - 8626
  • [10] Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer
    Calvisi, Diego F.
    Ladu, Sara
    Conner, Elizabeth A.
    Seo, Daekwan
    Hsieh, Jer-Tsong
    Factor, Valentina M.
    Thorgeirsson, Snorri S.
    [J]. JOURNAL OF HEPATOLOGY, 2011, 54 (02) : 311 - 319
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