Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides

被引：79
作者：
Biscoe, Mark R. [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 08期
基金：
美国国家卫生研究院;
关键词：
CATALYZED ALPHA-ARYLATION; CROSS-COUPLING REACTIONS; C-N; SUZUKI-MIYAURA; PALLADIUM; VINYLATION; EFFICIENT; PROTOCOL;
D O I：
10.1021/ol900295u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Simple, efficient procedures for the monoarylation of acetate esters and aryl methyl ketones using aryl chlorides are presented. Previously, no general method was available to ensure the highly selective monoarylation of these classes of substrates using aryl chlorides. Using palladium precatalysts recently reported by our group, these reactions are easily accomplished under mild conditions that tolerate a wide array of heterocyclic substrates.
引用
收藏
页码：1773 / 1775
页数：3
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