Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity

被引:26
作者
Theodosis-Nobelos, Panagiotis [1 ]
Kourti, Malamati [1 ]
Gavalas, Antonios [1 ]
Rekka, Eleni A. [1 ]
机构
[1] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54124, Greece
关键词
Non steroidal anti-inflammatory drugs; alpha-Lipoic acid; Thiomorpholine amides; Hypolipidemic activity; Inflammation; LOW-DENSITY-LIPOPROTEIN; CARDIOVASCULAR-DISEASE; LIPOIC ACID; ANTIOXIDANT; INFLAMMATION; 27-HYDROXYCHOLESTEROL; HYPERCHOLESTEROLEMIA; 5-LIPOXYGENASE; HYPERLIPIDEMIA; DERIVATIVES;
D O I
10.1016/j.bmcl.2015.12.063
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), alpha-lipoic acid and indole-3-acetic acid with thiomorpholine were synthesised by a simple method and at high yields (60-92%). All the NSAID derivatives highly decreased lipidemic indices in the plasma of Triton treated hyperlipidemic rats. The most potent compound was the indomethacin derivative, which decreased total cholesterol, triglycerides and LDL cholesterol by 73%, 80% and 83%, respectively. They reduced acute inflammation equally or more than most parent acids. Hence, it could be concluded that amides of common NSAIDs with thiomorpholine acquire considerable hypolipidemic potency, while they preserve or augment their anti-inflammatory activity, thus addressing significant risk factors for atherogenesis. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:910 / 913
页数:4
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