Romance of the three kingdoms in hypoxia: HIFs, epigenetic regulators, and chromatin reprogramming

被引：21
作者：
Chen, Yan [1 ,2 ,3 ]
Liu, Min [4 ]
Niu, Yanling [5 ]
Wang, Yijie [5 ]
机构：
[1] Jinan Univ, Zhuhai Precis Med Ctr, Zhuhai Peoples Hosp, Zhuhai Hosp, Zhuhai 519000, Guangdong, Peoples R China
[2] Jinan Univ, Sch Med, 601 W Huangpu Ave, Guangzhou 510632, Guangdong, Peoples R China
[3] Jinan Univ, Biomed Translat Res Inst, Guangzhou 510632, Guangdong, Peoples R China
[4] Shandong Normal Univ, Coll Life Sci, Collaborat Innovat Ctr Cell Biol Univ Shandong, Jinan 250014, Shandong, Peoples R China
[5] UT Southwestern Med Ctr, Dept Pathol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
来源：
CANCER LETTERS | 2020年 / 495卷
基金：
中国国家自然科学基金;
关键词：
Hypoxia; Hypoxia-inducible factor; Epigenetic regulator; Chromatin reprogramming; Gene transcription; INDUCIBLE FACTOR-1 HIF-1; FACTOR-KAPPA-B; CELLULAR-RESPONSE; TRANSCRIPTIONAL ACTIVITY; PROTEIN STABILITY; HISTONE H2AX; HIF-1-ALPHA; TUMOR; EXPRESSION; ACETYLATION;
D O I：
10.1016/j.canlet.2020.09.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hypoxia is a hallmark of cancer. To cope with hypoxic conditions, tumor cells alter their transcriptional profiles mainly through hypoxia-inducible factors (HIFs) and epigenetic reprogramming. Hypoxia, in part through HIF-dependent mechanisms, influences the expression or activity of epigenetic regulators to control epigenetic reprogramming, including DNA methylation and histone modifications, which regulate hypoxia-responsive gene expression in cells. Conversely, epigenetic regulators and chromatin architecture can modulate the expression, stability, or transcriptional activity of HIF. Understanding the complex networks between HIFs, epigenetic regulators, and chromatin reprogramming in response to hypoxia will provide insight into the fundamental mechanism of transcriptional adaptation to hypoxia, and may help identify novel targets for future therapies. In this review, we will discuss the comprehensive relationship between HIFs, epigenetic regulators, and chromatin reprogramming under hypoxic conditions.
引用
收藏
页码：211 / 223
页数：13
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