Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia

被引：0

作者：

Sonmez, Mehmet ^{[1
]}

Arslan, Mehmet ^{[2
]}

Cobanoglu, Umit ^{[3
]}

Kavgaci, Halil ^{[4
]}

Ozbas, Hasan Mucahit ^{[5
]}

Aydin, Fazil ^{[4
]}

Ovali, Ercument ^{[1
]}

Omay, Serdar Bedii ^{[1
]}

机构：

[1] Karadeniz Tech Univ, Sch Med, Dept Hematol, TR-61080 Trabzon, Turkey

[2] Karadeniz Tech Univ, Sch Med, Dept Gastroenterol, TR-61080 Trabzon, Turkey

[3] Karadeniz Tech Univ, Sch Med, Dept Pathol, TR-61080 Trabzon, Turkey

[4] Karadeniz Tech Univ, Sch Med, Dept Oncol, TR-61080 Trabzon, Turkey

[5] Karadeniz Tech Univ, Sch Med, Dept Internal Med, TR-61080 Trabzon, Turkey

来源：

TUMORI JOURNAL | 2009年 / 95卷 / 02期

关键词：

gastrointestinal stromal tumor; acute myeloid leukemia; myelodysplastic syndrome; DIAGNOSIS; KIT;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs are believed to be related to mutational activation of receptor tyrosine kinases, KIT, or platelet-derived growth factor receptor-alpha. The coexistence of GISTs with other neoplams has been extensively addressed in the literature. The most common second neoplasms are colorectal cancer, prostate cancer, and neoplasms derived from lymphoid tissue. In this case report, we describe a patient affected by GIST and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. The clinicopathological characteristics of the patient are discussed and the literature is reviewed.

引用

页码：240 / 242

页数：3

共 17 条

[1] Occurrence of other malignancies in patients with gastrointestinal stromal tumors [J].

Agaimy, Abbas ;

Wuensch, Peter H. ;

Sobin, Leslie H. ;

Lasota, Jerzy ;

Miettinen, Markku .

SEMINARS IN DIAGNOSTIC PATHOLOGY, 2006, 23 (02) :120-129

[2] Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST) [J].

Ali, Safdar ;

Ali, Sher .

GENE, 2007, 401 (1-2) :38-45

[3] Papillary renal cell carcinoma and gastrointestinal stromal tumor: a unique association [J].

An, WY ;

Ho, KM ;

Shek, TW .

ANNALS OF ONCOLOGY, 2004, 15 (05) :843-844

[4] Gastrointestinal stromal tumors (GISTs): focus on histopathological diagnosis and biomolecular features [J].

Badalamenti, G. ;

Rodolico, V. ;

Fulfaro, F. ;

Cascio, S. ;

Cipolla, C. ;

Cicero, G. ;

Incorvaia, L. ;

Sanfilippo, M. ;

Intrivici, C. ;

Sandonato, L. ;

Pantuso, G. ;

Latteri, M. A. ;

Gebbia, N. ;

Russo, A. .

ANNALS OF ONCOLOGY, 2007, 18 :136-140

[5]

Bircan Sema, 2004, Turk J Gastroenterol, V15, P187

[6] Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib [J].

Bono, P ;

Krause, A ;

von Mehren, M ;

Heinrich, MC ;

Blanke, CD ;

Dimitrijevic, S ;

Demetri, GD ;

Joensuu, H .

BLOOD, 2004, 103 (08) :2929-2935

[7] Biology of gastrointestinal stromal tumors [J].

Corless, CL ;

Fletcher, JA ;

Heinrich, MC .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (18) :3813-3825

[8] Gastrointestinal stromal tumor (GIST) [J].

Joensuu, H. .

ANNALS OF ONCOLOGY, 2006, 17 :X280-X286

[9]

Kalmar Katalin, 2004, Magy Seb, V57, P251

[10] Kit as a human oncogenic tyrosine kinase [J].

Kitamura, Y ;

Hirotab, S .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (23) :2924-2931

← 1 2 →