Pediatric Plasmablastic Lymphoma: A Clinicopathologic Study

被引：18

作者：

Vaubell, Jalaludin I. ^{[1
,2
]}

Sing, Yetish ^{[1
,2
]}

Ramburan, Amsha ^{[1
,2
]}

Sewram, Vikash ^{[3
]}

Thejpal, Rajendra ^{[4
]}

Rapiti, Nadine ^{[2
,5
]}

Ramdial, Pratistadevi K. ^{[1
,2
]}

机构：

[1] Sch Lab Med & Med Sci, Dept Anat Pathol, Durban, Kwazulu Natal, South Africa

[2] Natl Hlth Lab Serv, Durban, Kwazulu Natal, South Africa

[3] MRC, Oncol Res Unit, Durban, South Africa

[4] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Paediat, Durban, South Africa

[5] Sch Lab Med & Med Sci, Dept Haematol, Durban, Kwazulu Natal, South Africa

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2014年 / 22卷 / 07期

关键词：

plasmablastic lymphoma; childhood; pediatric; HIV; AIDS; ORAL-CAVITY; SURVIVAL; FEATURES; PATIENT;

D O I：

10.1177/1066896914531815

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Plasmablastic lymphoma (PBL) is reported rarely in children. To date, 10 cases are documented in the English-language literature. This study, based on 13 biopsies from 11 HIV-positive children (9 males, 2 females), documents the clinicopathologic features of PBL. The CD4 count ranged from 9 to 800 cells/mm(3). All biopsies demonstrated exclusive plasmablastic morphology; CD20 immunonegativity; and VS38c, EMA, CD31, MUM-1, CD45, and CD79a immunopositivity. B-cell monoclonality was confirmed in all biopsies. Of 3 biopsies subjected to FISH investigation, 2 had a t(8,14) translocation. Nine patients with follow-up details were treated exclusively with HAART (highly active antiretroviral therapy) or with combinations of HAART, chemotherapy, and radiotherapy. Seven patients died. PBL histomorphology, disease stage, and treatment modalities employed were not predictive of outcome. The survival of 2 stage 4 patients for 3 and 8 years each, managed on HAART, chemotherapy, and radiotherapy, however, may justify a role for combined therapeutic modalities for PBL.

引用

页码：607 / 616

页数：10

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