Damage Control Surgery after Burn Injury: A Narrative Review

被引:6
作者
Rennekampff, Hans-Oliver [1 ]
Tenenhaus, Mayer [1 ]
Huss, Fredrik [1 ]
机构
[1] Rhein Maas Klinikum, Dept Plast Surg Hand & Burn Surg, D-52146 Wurselen, Germany
来源
EUROPEAN BURN JOURNAL | 2022年 / 3卷 / 02期
关键词
burn; damage control; debridement; surgery; second hit; CERIUM NITRATE; WOUND EXCISION; LETHAL TRIAD; SURVIVAL; TRANSFUSION; TRAUMA; BLOOD; EXPRESSION; MORTALITY; DAMPS;
D O I
10.3390/ebj3020024
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Burn injuries with cutaneous loss result in a severe systemic response when profound injuries exceed 20% of the total body surface area. The management of severely burned patients is a complex and dynamic process. Timely and safe operative interventions are critical components of multidisciplinary care. Effective management of severely burned patients, their cutaneous injuries, and the associated systemic disease requires a comprehensive understanding of the pathophysiologic response to trauma, objective indicators of patient status, and an appreciation for the dynamic nature of these parameters. Progress in both clinical and basic science research has advanced our understanding of these concepts and our approach to the management of burn patients. Incorporating concepts such as early total care, damage control surgery (DCS), and safe definitive surgery (SDS) in the polytraumatized patient may further aid in optimizing outcomes and quality of care for burn patients. This article connects current knowledge of the lethal triad, inflammation, immunosuppression, and eschar-derived toxins, with surgical burn care, especially burn wound debridement. The concepts of DCS and SDS for the care and management of burn patients are strongly advocated. Experimental and clinical studies are encouraged to validate these concepts in an effort to optimize patient outcomes.
引用
收藏
页码:278 / 289
页数:12
相关论文
共 94 条
[61]   Massive transfusion and massive transfusion protocol [J].
Patil, Vijaya ;
Shetmahajan, Madhavi .
INDIAN JOURNAL OF ANAESTHESIA, 2014, 58 (05) :590-595
[62]  
PETERSON VM, 1985, J TRAUMA, V25, P1039
[63]   Acute blood loss during burn and soft tissue excisions: An observational study of blood product resuscitation practices and focused review [J].
Pidcoke, Heather F. ;
Isbell, Claire L. ;
Herzig, Maryanne C. ;
Fedyk, Chriselda G. ;
Schaffer, Beverly S. ;
Chung, Kevin K. ;
White, Christopher E. ;
Wolf, Steven E. ;
Wade, Charles E. ;
Cap, Andrew P. .
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 2015, 78 :S39-S47
[64]   Editorial: Trauma-Induced, DAMP-Mediated Remote Organ Injury, and Immunosuppression in the Acutely Ill Patient [J].
Pottecher, Julien ;
Meyer, Alain ;
Wenceslau, Camilla Ferreira ;
Timmermans, Kim ;
Hauser, Carl Jeffrey ;
Land, Walter Gottlieb .
FRONTIERS IN IMMUNOLOGY, 2019, 10
[65]   Early abnormal fibrinolysis and mortality in patients with thermal injury: a prospective cohort study [J].
Pusateri, A. E. ;
Le, T. D. ;
Keyloun, J. W. ;
Moffatt, L. T. ;
Orfeo, T. ;
Brummel-Ziedins, K. E. ;
McLawhorn, M. M. ;
Callcut, R. A. ;
Shupp, J. W. .
BJS OPEN, 2021, 5 (02)
[66]   Cerium Nitrate Treatment Provides Eschar Stabilization through Reduction in Bioburden, DAMPs, and Inflammatory Cytokines in a Rat Scald Burn Model [J].
Qian, Li-Wu ;
Evani, Shankar J. ;
Chen, Ping ;
Brandenburg, Kenneth S. ;
Weaver, Alan J. ;
Fourcaudot, Andrea B. ;
Abercrombie, Johnathan J. ;
Sebastian, Eliza A. ;
Leung, Kai P. .
JOURNAL OF BURN CARE & RESEARCH, 2020, 41 (03) :576-584
[67]   Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation [J].
Rani, Meenakshi ;
Nicholson, Susannah E. ;
Zhang, Qiong ;
Schwacha, Martin G. .
BURNS, 2017, 43 (02) :297-303
[68]   Compounded Cerium Nitrate-Silver Sulfadiazine Cream is Safe and Effective for the Treatment of Burn Wounds: A Burn Center's 4-Year Experience [J].
Reese, Adam D. ;
Keyloun, John W. ;
Garg, Gaurav ;
McLawhorn, Melissa M. ;
Moffatt, Lauren T. ;
Travis, Taryn E. ;
Johnson, Laura S. ;
Shupp, Jeffrey W. .
JOURNAL OF BURN CARE & RESEARCH, 2022, 43 (03) :716-721
[69]  
RENNEKAMPFF OH, 1995, SURGERY, V118, P884, DOI 10.1016/S0039-6060(05)80280-6
[70]   Neutrophils from burn patients are unable to increase the expression of CD11b/CD18 in response to inflammatory stimuli [J].
Rodeberg, DA ;
Bass, RC ;
Alexander, JW ;
Warden, GD ;
Babcock, GF .
JOURNAL OF LEUKOCYTE BIOLOGY, 1997, 61 (05) :575-582