HLA-class 1 and class 2 antigens in Turkish patients with pemphigus

被引:24
作者
Birol, A
Anadolu, RY
Tutkak, H
Gürgey, E
机构
[1] Kyrykkale Univ, Fac Med, Dept Dermatol, Kyrykkale, Turkey
[2] Ankara Univ, Fac Med, Dept Dermatol, TR-06100 Ankara, Turkey
[3] Ankara Univ, Fac Med, Clin Clin Immunol & Rheumatol, TR-06100 Ankara, Turkey
关键词
D O I
10.1046/j.1365-4362.2002.01370.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background Pemphigus is an autoimmune disease which is more frequently seen in certain ethnic groups such as Jews. It is thought that exogenous factors may induce pemphigus in genetically predisposed individuals. Recent reports on HLA antigens indicate an increased frequency of Herein we investigated the HILA-class II antigens particularly HLA-DR4 among Jewish patients. antigen frequencies of HLA-A, B, C, HLA-DR and DO in Turkish patients with pemphigus. Methods HLA class I and II antigens were typed by microdroplet lymphocyte cytotoxicity test in 33 patients with pemphigus and 100 healthy individuals. Results HLA-B35, B44, CW4, DR4, DR14, DQ8 and DQ4 antigens were significantly high in the study group whereas HLA-DR11, DQ7 and DQ2 antigens were high among the controls. The most striking differences were observed in HLA class II antigens. HLADR14-DQ8 and HLA B35-DR14 haplotypes were the most frequently observed ones in the study group. Conclusions We postulate that HLA-B35, B44, CW4, DR4, DR14, DQ4 and DQ8 antigens may be responsible for susceptibility to pemphigus while HLA-DR11, DQ7 and DQ2 antigens may have a protective role in the Turkish population.
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页码:79 / 83
页数:5
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