Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational Study: The FRACTING Study

被引：17

作者：

Massari, Leo ^{[1
]}

Benazzo, Francesco ^{[2
]}

Falez, Francesco ^{[3
]}

Cadossi, Ruggero ^{[4
]}

Perugia, Dario ^{[5
]}

Pietrogrande, Luca ^{[6
]}

Aloj, Domenico Costantino ^{[7
]}

Capone, Antonio ^{[8
]}

D'Arienzo, Michele ^{[9
]}

Cadossi, Matteo ^{[10
]}

Lorusso, Vincenzo ^{[1
]}

Caruso, Gaetano ^{[1
]}

Ghiara, Matteo ^{[2
]}

Ciolli, Luigi ^{[3
]}

La Cava, Filippo ^{[3
]}

Guidi, Marco ^{[5
]}

Castoldi, Filippo ^{[7
]}

Marongiu, Giuseppe ^{[8
]}

La Gattuta, Alessandra ^{[9
]}

Dell'Omo, Dario ^{[11
]}

Scaglione, Michelangelo ^{[11
]}

Giannini, Sandro ^{[10
]}

Fortina, Mattia ^{[12
]}

Riva, Alberto ^{[12
]}

De Palma, Pier Luigi ^{[13
]}

Gigante, Antonio Pompilio ^{[13
]}

Moretti, Biagio ^{[14
]}

Solarino, Giuseppe ^{[14
]}

Lijoi, Francesco ^{[15
]}

Giordano, Giovanni ^{[15
]}

Londini, Pier Giorgio ^{[16
]}

Castellano, Danilo ^{[16
]}

Sessa, Giuseppe ^{[17
]}

Costarella, Luciano ^{[17
]}

Barile, Antonio ^{[18
]}

Borrelli, Mariano ^{[18
]}

Rota, Attilio ^{[19
]}

Fontana, Raffaele ^{[19
]}

Momoli, Alberto ^{[20
]}

Micaglio, Andrea ^{[20
]}

Bassi, Guido ^{[21
]}

Cornacchia, Rossano Stefano ^{[22
]}

Castelli, Claudio ^{[23
]}

Giudici, Michele ^{[23
]}

Monesi, Mauro ^{[24
]}

Vergano, Luigi Branca ^{[24
]}

Maniscalco, Pietro ^{[25
]}

Bulabula, M'Putu ^{[25
]}

Zottola, Vincenzo ^{[26
]}

Caraffa, Auro ^{[27
]}

机构：

[1] Univ Ferrara, S Anna Hosp, Orthopaed & Traumatol Dept, Ferrara, Italy

[2] Univ Pavia, IRCCS Fdn San Matteo Hosp, Orthopaed & Traumatol Dept, Pavia, Italy

[3] Santo Spirito Sassia Hosp, Orthopaed & Traumatol Dept, Rome, Italy

[4] IGEA Clin Biophys, Res & Dev, Modena, Italy

[5] St Andrea Hosp, Orthopaed & Traumatol Dept, Rome, Italy

[6] Univ Milan, San Paolo Hosp, Operat Unit Orthopaed & Traumatol, Hlth Sci Dept, Milan, Italy

[7] CTO Hosp, Orthopaed Clin 2, Orthopaed Traumatol & Rehabil Dept, Turin, Italy

[8] Univ Cagliari, Orthopaed Dept, Cagliari, Italy

[9] Univ Palermo, Paolo Giaccone Hosp, Orthopaed & Traumatol Dept, Palermo, Italy

[10] Univ Bologna, Rizzoli Orthopaed Inst, Dept Orthopaed Surg, Bologna, Italy

[11] Univ Pisa, Orthopaed & Traumatol 2, Translat Res New Surg & Med Technol Dept, Pisa, Italy

[12] Univ Siena, SM alle Scotte Hosp, Orthopaed & Traumatol Clin, Siena, Italy

[13] Polytech Univ Marche, Fac Med, Clin & Mol Sci Dept, Ancona, Italy

[14] Univ Bari, Neurosci & Sensory Organs Dept, Basic Med Sci, Bari, Italy

[15] Morgagni Pierantoni Hosp, Orthopaed & Trauma Dept, Forli, Italy

[16] Misericordia Hosp ASL 9, Orthopaed & Traumatol Dept, Grosseto, Italy

[17] Univ Catania, Vittorio Emanuele Hosp, Surg Dept, Catania, Italy

[18] San Michele Nursing Home Hosp, Orthopaed & Trauma Dept, Maddaloni, Caserta, Italy

[19] ASL RMB, Sandro Pertini Hosp, Orthopaed & Traumatol Dept, Rome, Italy

[20] San Bortolo Hosp, Orthopaed & Traumatol Dept, Vicenza, Italy

[21] AO Pavia Voghera Hosp, Orthopaed & Traumatol Dept, Pavia, Italy

[22] Ariano Irpino Hosp, Orthopaed & Traumatol Unit, Avellino, Italy

[23] Papa Giovanni XXIII Hosp, Orthopaed & Trauma Dept, Bergamo, Italy

[24] Osped Gen Provinciale M Bufalini, Orthopaed & Traumatol Dept, Cesena, Italy

[25] Guglielmo da Saliceto Hosp, Orthopaed & Traumatol Dept, Piacenza, Italy

[26] St Anna Hosp, Traumatol & Reconstruct Surg Funct Dept, Como, Italy

[27] Univ Perugia, SM Misericordia Hosp, Orthopaed & Traumatol Clin, Perugia, Italy

[28] Univ Modena & Reggio Emilia, Policlin Modena, Orthopaed Surg Dept, Modena, Italy

[29] Montecchio Maggiore Hosp, Orthopaed & Traumatol Dept, Vicenza, Italy

[30] CTO Hosp ASL RM C, Orthopaed & Traumatol Dept, Rome, Italy

[31] Reg Veneto Azienda ULSS 18, Orthopaed & Traumatol Dept, Rovigo, Italy

[32] Di Venere Hosp, Orthopaed & Traumatol Dept, Bari, Italy

[33] SS Annunziata Hosp, Orthopaed & Traumatol Dept, Taranto, Italy

[34] Univ Torino, Mauriziano Umberto I Hosp, Orthopaed & Traumatol SCDU Dept, Turin, Italy

[35] San Donato Hosp, Orthopaed & Traumatol Surg Dept, Arezzo, Italy

[36] NOCSAE Hosp, Orthopaed Dept, Modena, Italy

[37] Santa Chiara Hosp, Orthopaed & Traumatol Dept, Trento, Italy

[38] Santa Maria di Loreto Mare Hosp, Orthopaed Unit, Naples, Italy

[39] S Maria delle Croci Hosp, Specialized Surg Dept, Ravenna, Italy

[40] Sapienza Univ Rome, Orthopaed Dept, Rome, Italy

[41] AOUD Udine, Santa Maria della Misericordia Hosp, Orthopaed & Trauma Dept, Udine, Italy

[42] Piedimonte Matese Hosp, Orthopaed & Traumatol Unit, Caserta, Italy

来源：

BIOMED RESEARCH INTERNATIONAL | 2018年 / 2018卷

关键词：

BONE MORPHOGENETIC PROTEIN-2; SHAFT FRACTURES; RISK-FACTORS; FIXATION; REPAIR; TRIAL;

D O I：

10.1155/2018/1809091

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background. Healing of tibia fractures occurs over a wide time range of months, with a number of risk factors contributing to prolonged healing. In this prospective, multicentre, observational study, we investigated the capability of FRACTING (tibia FRACTure prediction heallNG days) score, calculated soon after tibia fracture treatment, to predict healing time. Methods. The study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined to calculate the FRACTING score. Fractures were considered healed when the patient was able to fully weight-bear without pain. Results. 319 fractures (88%) healed within 12 months from treatment. Forty-four fractures healed after 12 months or underwent a second surgery. FRACTING score positively correlated with days to healing: r = 0.63 (p < 0.0001). Average score value was 7.3 +/- 2.5; ROC analysis showed strong reliability of the score in separating patients healing before versus after 6 months: AUC = 0.823. Conclusions. This study shows that the FRACTING score can be employed both to predict months needed for fracture healing and to identify immediately after treatment patients at risk of prolonged healing. In patients with high score values, new pharmacological and nonpharmacological treatments to enhance osteogenesis could be tested selectively, which may finally result in reduced disability time and health cost savings.

引用

页数：7

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