Synthesis of some new tetrazolo-[1,5-a]quinazolino[2,3-c]imidazo-[4,5-b]quinoxaline derivatives as antimicrobial agents

被引：0

作者：

Srinivas, B. ^{[1
]}

Prasanna, B. ^{[1
]}

Ravinder, M. ^{[1
]}

机构：

[1] Chaitanya Post Grad Coll Autonomous, Dept Chem, Res Ctr, Warangal 506001, Andhra Pradesh, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2014年 / 53卷 / 02期

关键词：

Tetrazole; amino quinazoline; quinoxaline; sodium azide; antimicrobial; QUINOXALINE CHEMISTRY;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 6,7-dimethoxy-2-chloroquinazolin-4-amine 1 and 7,8-dimethoxy tetrazolo-[1, 5-a]-quinazolin-5-amine 4 with 2, 3-dichloroquinoxaline 2a-e in glacial acetic acid /DMF afford corresponding substituted 6,7-dimethoxy-2-chloroquinazolo[3,4-c]-imidazo-[4,5-b]-quinoxalines 3a-e and 7,8-dimethoxytetrazolo-[1,5-a]-quinazolo-[2,3-c]-imidazo-[4,5-b]-quninoxalines 5a-e. The chemical structures of the newly synthesized compounds have been characterized by IR, NMR, mass spectral and CHN analysis. All the title compounds are subjected to in vitro antibacterial testing against two pathogenic strains and antifungal screening against two fungi. Among the tested compounds, 5b and 5c show significant antibacterial and antifungal activities. Also the compound 3b show significant antifungal activity against Candia albicans.

引用

页码：238 / 242

页数：5

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