Assessment of urinary concentration of cotinine in Chinese pregnant women exposed to environmental tobacco smoke

被引:5
作者
Lei, Yajing [1 ]
Liu, Wenhui [1 ]
Fang, Lizheng [2 ]
Akash, Muhammad Sajid Hamid [1 ,3 ]
Rehman, Kanwal [1 ]
Narenmandura, Hua [1 ]
Shi, Weixing [4 ]
Lu, Weixian [5 ]
Xu, Yingchun [1 ]
Chen, Shuqing [1 ]
机构
[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmacol Toxicol & Biochem Pharmaceut, Hangzhou 310058, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China
[3] Univ Faisalabad, Govt Coll, Coll Pharm, Faisalabad 38000, Pakistan
[4] Zhejiang Univ, Coll Med Sci, Inst Publ Hlth, Hangzhou 310058, Zhejiang, Peoples R China
[5] Hangzhou EPIE Biodetect Technol Ltd, Hangzhou 310051, Zhejiang, Peoples R China
来源
CHINESE SCIENCE BULLETIN | 2014年 / 59卷 / 13期
关键词
Biomarkers; Biomonitoring; Cotinine; Environmental tobacco smoke; Pregnancy; PASSIVE SMOKING; 2ND-HAND SMOKE; CORD BLOOD; POPULATION; NICOTINE; POLLUTANTS; BIOMARKERS; DISEASE; COHORT; RISK;
D O I
10.1007/s11434-014-0209-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Environmental tobacco smoke (ETS) is a well-known reason of many adverse health consequences in pregnant women. Exposure of ETS during pregnancy may increase the risk of some fetal diseases in pregnant women and/or birth defects in neonates. Many countries have implemented laws to control smoking and free of second hand smoke in all enclosed workplaces. In China, anti-smoking law was enforced in March 2010. We aimed to assess the exposure of pregnant women to cotinine after anti-smoking law was implemented in China. The urine samples were collected from 2,100 volunteers from Zhejiang Province, China and urinary concentration of cotinine was measured using gas chromatography and mass spectrometry. Cotinine was detected in 87 % of the pregnant women. The GM and 95th percentile concentration in pregnant women were 4.28 and 44.00 mu g/L, respectively. Similarly, the GM and 95th concentration of cotinine were significantly higher in smoking group than in non-smoking group (P < 0.0001). Our results indicate that pregnant women in China are at the high risk of exposure ETS. Further attempts are required to make strategies to find out the sources of ETS exposure and prevent smoking at public places especially during pregnancy.
引用
收藏
页码:1386 / 1391
页数:6
相关论文
共 33 条
[1]   Changes in child exposure to environmental tobacco smoke (CHETS) study after implementation of smoke-free legislation in Scotland: national cross sectional survey [J].
Akhtar, Patricia C. ;
Currie, Dorothy B. ;
Currie, Candace E. ;
Haw, Sally J. .
BMJ-BRITISH MEDICAL JOURNAL, 2007, 335 (7619) :545-+
[2]  
Andres R L, 2000, Semin Neonatol, V5, P231, DOI 10.1053/siny.2000.0025
[3]  
[Anonymous], 2008, WHO report on the global tobacco epidemic, 2008: The MPOWER package
[4]  
[Anonymous], 2013, J MOL GENET MED, DOI DOI 10.4172/1747-0862.1000064
[5]   Environmental and biological monitoring of exposures to PAHs and ETS in the general population [J].
Aquilina, Noel J. ;
Delgado-Saborit, Juana Mari ;
Meddings, Claire ;
Baker, Stephen ;
Harrison, Roy M. ;
Jacob, Peyton, III ;
Wilson, Margaret ;
Yu, Lisa ;
Duan, Minjiang ;
Benowitz, Neal L. .
ENVIRONMENT INTERNATIONAL, 2010, 36 (07) :763-771
[6]   Association of self-reported passive smoking in pregnant women with cotinine level of maternal urine and umbilical cord blood at delivery [J].
Baheiraei, Azam ;
Banihosseini, Seyede Z. ;
Heshmat, Ramin ;
Mota, Ali ;
Mohsenifar, Afshin .
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY, 2012, 26 (01) :70-76
[7]   German Environmental Survey 1998 (GerES III): environmental pollutants in the urine of the German population [J].
Becker, K ;
Schulz, C ;
Kaus, S ;
Seiwert, M ;
Seifert, B .
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2003, 206 (01) :15-24
[8]   Biomarkers of environmental tobacco smoke exposure [J].
Benowitz, NL .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1999, 107 :349-355
[9]   Cotinine as a biomarker of environmental tobacco smoke exposure [J].
Benowitz, NL .
EPIDEMIOLOGIC REVIEWS, 1996, 18 (02) :188-204
[10]   The relationship between self-reported tobacco exposure and cotinines in urine and blood for pregnant women [J].
Chiu, Hsien-Tsai ;
Wu, Hong-Dar Isaac ;
Kuo, Hsien-Wen .
SCIENCE OF THE TOTAL ENVIRONMENT, 2008, 406 (1-2) :331-336