To look for a needle in a haystack: the search for autoantibodies in multiple sclerosis

被引：33

作者：

Schirmer, Lucas ^{[1
]}

Srivastava, Rajneesh ^{[1
]}

Hemmer, Bernhard ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-81675 Munich, Germany

[2] Munich Cluster Syst Neurol SyNergy, Munich, Germany

来源：

MULTIPLE SCLEROSIS JOURNAL | 2014年 / 20卷 / 03期

关键词：

multiple sclerosis; pathology; proteomics; Autoantibodies; review; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; ACUTE DISSEMINATED ENCEPHALOMYELITIS; NEUROMYELITIS-OPTICA; CEREBROSPINAL-FLUID; BASIC-PROTEIN; DEMYELINATING DISEASES; ANTIMYELIN ANTIBODIES; PROTEOLIPID PROTEIN; B-CELLS; IDENTIFICATION;

D O I：

10.1177/1352458514522104

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The search for autoantibodies in multiple sclerosis (MS) has been challenging for the last 3 decades. With the development of new proteomic methods and advances in expression and assay technologies, progress in the identification of MS autoantibodies has been made. A number of MS-specific autoantibodies have been proposed, most of them targeting proteins expressed in oligodendrocytes and along the myelin sheath. In this review, we summarize the status of antibody research in MS and then discuss recent developments and future strategies in defining and characterizing the potential antigenic targets of autoantibodies in MS.

引用

页码：271 / 279

页数：9

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