Synthesis and characterization of ruthenium(II) hydrazone complexes as anticancer chemotherapeutic agents: in vitro DNA/BSA protein binding and cytotoxicity assay

被引：25

作者：

Jayanthi, E. ^{[1
]}

Anusuya, M. ^{[1
]}

Bhuvanesh, N. S. P. ^{[2
]}

Khalil, K. A. ^{[3
,4
]}

Dharmaraj, N. ^{[1
]}

机构：

[1] Bharathiar Univ, Dept Chem, Inorgan & Nanomat Res Lab, Coimbatore 641046, Tamil Nadu, India

[2] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

[3] King Saud Univ, Dept Mech Engn, Coll Engn, Riyadh, Saudi Arabia

[4] Aswan Univ, Fac Energy Engn, Aswan, Egypt

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2015年 / 68卷 / 20期

关键词：

Heterocyclic hydrazones; Ru(II) complex; DNA/Protein binding; Cytotoxicity; Triphenylphosphine; DNA-BINDING; CRYSTAL-STRUCTURE; SUBSTITUTION; COORDINATION; ANTIOXIDANT; APOPTOSIS; ALBUMINS; CLEAVAGE; LIGAND; CU(II);

D O I：

10.1080/00958972.2015.1077950

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Ruthenium hydrazone complexes [RuH(CO)(L-1)(PPh3)(2)] (1) and [RuH(CO)(L-2)(PPh3)(2)] (2) synthesized by reacting [RuHCl(CO)(PPh3)(3)] with benzoic acid[(thiophene-2-yl)methylene] hydrazide (HL1) or benzoic acid[1-(furan-2-yl)methylene]hydrazide (HL2) were characterized by elemental analysis, IR spectral, and XRD techniques. An intercalative interaction of the free ligands as well as 1 and 2 with CT-DNA was identified through absorption/emission titrations and viscosity measurements. Their bovine serum albumin binding through absorption/emission and synchronous spectral studies indicated significant binding proficiency. In vitro cytotoxic study of the complexes carried out against HeLa and MCF7 cell lines demonstrated that both complexes are potentially cytotoxic against both cell lines. The superior biological potential of 1 compared to 2 was attributed to the presence of sulfur containing heterocyclic moiety in the former complex.

引用

页码：3551 / 3565

页数：15

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