Recent Advances in the Synthesis of Lamellarins as Anticancer Alkaloids

被引：0

作者：

Shen, Li ^{[1
]}

Hu, Yongzhou ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 29卷 / 06期

关键词：

lamellarin; anticancer; synthesis; AUSTRALIAN MARINE SPONGE; ALPHA; 20-SULFATE; PERMETHYL STORNIAMIDE; AROMATIC METABOLITES; EFFICIENT SYNTHESIS; 1ST SYNTHESIS; INHIBITOR; DERIVATIVES; LUKIANOL; NINGALIN;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The lamellarins, a group of natural pyrrole alkaloids with interesting anticancer activities, were firstly isolated from a prosobranch mollus Lamellaria sp.. Due to their multidrug resistance (MDR) reversal in some cancer cell lines, total synthesis and structure modifications of lamellarins to provide drug candidates for the treatment of cancer have become one of the most promising project in the area of novel anticancer drug discovery. In this article, the latest results and progresses regarding the synthesis and modification of lamellarins are reviewed.

引用

页码：867 / 875

页数：9

共 61 条

[1]

ALVAREZ M, 2004, Patent No. 2004073598

[2] METABOLITIES OF THE MARINE PROSOBRANCH MOLLUSK LAMELLARIA SP [J].

ANDERSEN, RJ ;

FAULKNER, DJ ;

HE, CH ;

VANDUYNE, GD ;

CLARDY, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (19) :5492-5495

[3]

Bach T, 1999, EUR J ORG CHEM, V1999, P2045

[4]

BAILLY C, 2004, Patent No. 2004014917

[5]

Bailly Christian, 2004, Current Medicinal Chemistry - Anti-Cancer Agents, V4, P363, DOI 10.2174/1568011043352939

[6]

BAILY C, 2005, Patent No. 1688585

[7] Convergent total synthesis of lamellarin K [J].

Banwell, M ;

Flynn, B ;

Hockless, D .

CHEMICAL COMMUNICATIONS, 1997, (23) :2259-2260

[8]

Banwell M. G., 1998, Chem. Abstr., V130, P3974, Patent No. 9850365

[9]

Banwell M.G., 2006, BIOORGAN MED CHEM, V14, P4267

[10] Convergent syntheses of the pyrrolic marine natural products lamellarin-O, lamellarin-Q, lukianol-A and some more highly oxygenated congeners [J].

Banwell, MG ;

Flynn, BL ;

Hamel, E ;

Hockless, DCR .

CHEMICAL COMMUNICATIONS, 1997, (02) :207-208

← 1 2 3 4 5 6 7 →