Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae

被引：8
作者：
Mitrofanova, Darya [1 ]
Dakik, Pamela [1 ]
McAuley, Melissa [1 ]
Medkour, Younes [1 ]
Mohammad, Karamat [1 ]
Titorenko, Vladimir, I [1 ]
机构：
[1] Concordia Univ, Dept Biol, 7141 Sherbrooke St West,Sci Pavil,Off SP-501-13, Montreal, PQ H4B 1R6, Canada
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2018年 / 23卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Aging; Longevity; Mechanisms; Lipid metabolism; Review; CHRONOLOGICAL LIFE-SPAN; PHOSPHOSPHINGOLIPID PHOSPHOLIPASE-C; DROPLET-ORGANELLE INTERACTIONS; OXIDATIVE STRESS SENSITIVITY; PLANT DEFENSIN-SENSITIVITY; FATTY-ACID-METABOLISM; CALORIC RESTRICTION; MITOCHONDRIAL DYSFUNCTION; SPHINGOLIPID METABOLISM; ENDOPLASMIC-RETICULUM;
D O I：
10.2741/4638
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Emergent evidence indicates that certain aspects of lipid synthesis, degradation and interorganellar transport play essential roles in modulating the pace of cellular aging in the budding yeast Saccharomyces cerevisiae. The molecular mechanisms underlying the vital roles of lipid metabolism and transport in defining yeast longevity have begun to emerge. The scope of this review is to critically analyze recent progress in understanding such mechanisms.
引用
收藏
页码：1166 / 1194
页数：29
相关论文
共 245 条
  • [1] The mystery of C. elegans aging: An emerging role for fat
    Ackerman, Daniel
    Gems, David
    [J]. BIOESSAYS, 2012, 34 (06) : 466 - 471
  • [2] Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast
    Aerts, AM
    François, IEJA
    Bammens, L
    Cammue, BPA
    Smets, B
    Winderickx, J
    Accardo, S
    De Vos, DE
    Thevissen, K
    [J]. FEBS LETTERS, 2006, 580 (07) : 1903 - 1907
  • [3] The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry
    Aguilaniu, Hugo
    Fabrizio, Paola
    Witting, Michael
    [J]. FRONTIERS IN ENDOCRINOLOGY, 2016, 7
  • [4] Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor
    Alic, Nazif
    Hoddinott, Matthew P.
    Vinti, Giovanna
    Partridge, Linda
    [J]. AGING CELL, 2011, 10 (01): : 137 - 147
  • [5] Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis
    Almeida, Teresa
    Marques, Marta
    Mojzita, Dominik
    Amorim, Maria A.
    Silva, Rui D.
    Almeida, Bruno
    Rodrigues, Pedro
    Ludovico, Paula
    Hohmann, Stefan
    Moradas-Ferreira, Pedro
    Corte-Real, Manuela
    Costa, Vitor
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (03) : 865 - 876
  • [6] Regulation of longevity by the reproductive system
    Antebi, Adam
    [J]. EXPERIMENTAL GERONTOLOGY, 2013, 48 (07) : 596 - 602
  • [7] Pparγ2 Is a Key Driver of Longevity in the Mouse
    Argmann, Carmen
    Dobrin, Radu
    Heikkinen, Sami
    Auburtin, Aurelie
    Pouilly, Laurent
    Cock, Terrie-Anne
    Koutnikova, Hana
    Zhu, Jun
    Schadt, Eric E.
    Auwerx, Johan
    [J]. PLOS GENETICS, 2009, 5 (12)
  • [8] A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis
    Arlia-Ciommo, Anthony
    Svistkova, Veronika
    Mohtashami, Sadaf
    Titorenko, Vladimir I.
    [J]. ONCOTARGET, 2016, 7 (05) : 5204 - 5225
  • [9] Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan
    Arlia-Ciommo, Anthony
    Piano, Amanda
    Leonov, Anna
    Svistkova, Veronika
    Titorenko, Vladimir I.
    [J]. CELL CYCLE, 2014, 13 (21) : 3336 - 3349
  • [10] Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae
    Arlia-Ciommo, Anthony
    Leonov, Anna
    Piano, Amanda
    Svistkova, Veronika
    Titorenko, Vladimir I.
    [J]. MICROBIAL CELL, 2014, 1 (06): : 163 - 178
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