Parameters of the attenuated schistosome vaccine evaluated in the olive baboon

被引：49
作者：
Kariuki, TM
Farah, IO
Yole, DS
Mwenda, JM
Van Dam, GJ
Deelder, AM
Wilson, RA
Coulson, PS
机构：
[1] Univ York, Dept Biol, York YO10 5YW, N Yorkshire, England
[2] Inst Primate Res, Nairobi, Kenya
[3] Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 09期
关键词：
D O I：
10.1128/IAI.72.9.5526-5529.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.
引用
收藏
页码：5526 / 5529
页数：4
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