Constituents and biological activity of the chloroform extract and essential oil of Cupressus sempervirens

被引：19

作者：

Ibrahim, N. A. ^{[1
]}

El-Seedi, H. R. ^{[2
]}

Mohammed, M. M. D. ^{[1
]}

机构：

[1] Natl Res Ctr, Dept Pharmacognosy, Cairo 12311, Egypt

[2] Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, El Menoufia, Egypt

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2009年 / 45卷 / 03期

关键词：

Cupressus sempervirens L; epi-betulin esters; essential oil; antimicrobial; antiviral; antitumor activity; LEAVES;

D O I：

10.1007/s10600-009-9356-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The essential oil of the leaves of Cupressus sempervirens L. was isolated by hydrodistillation and tested against gram positive and gram negative bacteria, showing remarkable antimicrobial activity against Bacillus subtilis with minimum inhibitory concentration (MIC) 75%. The antiviral activity of the essential oil was tested against Herpes simplex virus type 1 (HSV-1), showing antiviral activity with virucidal percentages of 68.0% and 53.2% at concentrations of 1:32 and 1:64, respectively. We firstly reported the isolation of two epi-betulin esters of fatty acids from the CHCl3 fraction of Cupressus sempervirens L. leaves, which were isolated and purified using HPLC, and identified using PMR and MS. The CHCl3 fraction showed significant cytotoxicity against HeLa cells.

引用

页码：309 / 313

页数：5

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