The Neural Correlates of Verbal and Nonverbal Semantic Processing Deficits in Neurodegenerative Disease

被引:84
作者
Butler, Christopher R. [1 ]
Brambati, Simona M. [2 ,3 ]
Miller, Bruce L. [2 ]
Gorno-Tempini, Maria-Luisa [2 ]
机构
[1] Univ Edinburgh, Div Clin Neurosci, Edinburgh EH8 9YL, Midlothian, Scotland
[2] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
[3] Inst Univ Geriatrie Montreal, Ctr Rech, Montreal, PQ, Canada
关键词
dementia; semantic memory; voxel-based morphometry; PROGRESSIVE SUPRANUCLEAR PALSY; TEMPORAL-LOBE ATROPHY; FRONTOTEMPORAL DEMENTIA; MULTIPLE SEMANTICS; CORTICOBASAL DEGENERATION; ALZHEIMERS-DISEASE; HUMAN BRAIN; KNOWLEDGE; APHASIA; ANATOMY;
D O I
10.1097/WNN.0b013e318197925d
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Objective: To investigate the neural correlates of verbal and nonverbal semantic processing in neurodegenerative disease. Background: Semantic memory is often impaired in neurodegenerative disease. Neuropsychologic and functional neuroimaging studies suggest that the semantic processing of verbal and nonverbal stimuli may depend oil partially distinct brain networks. Methods: We examined this possibility using voxel-based morphometry to correlate performance on verbal and nonverbal versions of a semantic association task with regional gray matter atrophy in 144 individuals with a variety of neurodegenerative diseases. Results: Results showed that, regardless of stimulus type, semantic processing correlated with atrophy in both temporal lobes. In addition, material-specific correlations were found in left temporal regions for verbal stimuli and the right fusiform gyrus for nonverbal stimuli. Conclusions: These results provide evidence for a differential role of the left and right hemispheres in the extraction of semantic information from verbal and pictorial representations. Areas in right inferior temporal lobe may be necessary to access structural descriptions of visually presented objects.
引用
收藏
页码:73 / 80
页数:8
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