Targeting autophagy in cardiac ischemia/reperfusion injury: A novel therapeutic strategy

被引：105

作者：

Aghaei, Mehrdad ^{[1
]}

Motallebnezhad, Morteza ^{[2
,3
,4
]}

Ghorghanlu, Sajjad ^{[5
]}

Jabbari, Ali ^{[5
]}

Enayati, Ayesheh ^{[5
,6
,7
]}

Rajaei, Maryam ^{[5
]}

Pourabouk, Mona ^{[5
]}

Moradi, Alireza ^{[8
]}

Alizadeh, Ali Mohammad ^{[9
]}

Khori, Vahid ^{[5
]}

机构：

[1] Golestan Univ Med Sci, Rheumatol Res Ctr, Gorgan, Golestan, Iran

[2] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[3] Iran Univ Med Sci, Dept Immunol, Fac Med, Tehran, Iran

[4] Iran Univ Med Sci, Student Res Comm, Tehran, Iran

[5] Golestan Univ Med Sci, Ischem Disorders Res Ctr, Gorgan 4934174515, Golestan, Iran

[6] Univ Tehran Med Sci, Fac Pharm, Dept Pharmacognosy, Tehran, Iran

[7] Univ Tehran Med Sci, Med Plants Res Ctr, Tehran, Iran

[8] Ardabil Univ Med Sci, Med Sch, Dept Physiol, Ardebil, Iran

[9] Univ Tehran Med Sci, Canc Res Ctr, Tehran 1419733141, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 10期

关键词：

acute myocardial infarction; autophagy; ischemia; reperfusion injury; ISCHEMIA-REPERFUSION INJURY; MITOCHONDRIAL PERMEABILITY TRANSITION; INHIBITING EXCESSIVE AUTOPHAGY; MYOCARDIAL-ISCHEMIA; SALVIA-MILTIORRHIZA; HISTONE DEACETYLASE; OXIDATIVE STRESS; COENZYME Q(10); UP-REGULATION; CELL-DEATH;

D O I：

10.1002/jcp.28345

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acute myocardial infarction (AMI) is one of the leading causes of morbidity worldwide. Myocardial reperfusion is known as an effective therapeutic choice against AMI. However, reperfusion of blood flow induces ischemia/reperfusion (I/R) injury through different complex processes including ion accumulation, disruption of mitochondrial membrane potential, the formation of reactive oxygen species, and so forth. One of the processes that gets activated in response to I/R injury is autophagy. Indeed, autophagy acts as a double-edged sword in the pathology of myocardial I/R injury and there is a controversy about autophagy being beneficial or detrimental. On the basis of the autophagy effect and regulation on myocardial I/R injury, many studies targeted it as a therapeutic strategy. In this review, we discuss the role of autophagy in I/R injury and its targeting as a therapeutic strategy.

引用

页码：16768 / 16778

页数：11

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