Validity of the rheumatoid arthritis impact of disease (RAID) score and definition of cut-off points for disease activity states in a population-based European cohort of patients with rheumatoid arthritis

被引：34

作者：

Salaffi, Fausto ^{[1
]}

Di Carlo, Marco ^{[1
]}

Vojinovic, Jelena ^{[2
]}

Tincani, Angela ^{[3
]}

Sulli, Alberto ^{[4
,5
]}

Soldano, Stefano ^{[4
,5
]}

Andreoli, Laura ^{[3
]}

Dall'Ara, Francesca ^{[3
]}

Ionescu, Ruxandra ^{[6
]}

Pasalic, Katarina Simic ^{[7
]}

Balcune, Ineta ^{[8
]}

Ferraz-Amaro, Ivan ^{[9
]}

Tlustochowicz, Malgorzata ^{[10
]}

Butrimiene, Irena ^{[11
]}

Punceviciene, Egle ^{[12
]}

Toroptsova, Natalia ^{[13
]}

Grazio, Simeon ^{[14
]}

Morovic-Vergles, Jadranka ^{[15
]}

Masaryk, Pavol ^{[16
]}

Otsa, Kati ^{[17
]}

Bernardes, Miguel ^{[18
,19
]}

Boyadzhieva, Vladimira ^{[20
]}

Cutolo, Maurizio ^{[4
,5
]}

机构：

[1] Polytech Univ Marche, Carlo Urbani Hosp, Rheumatol Dept, Via Aldo Moro 25, I-60035 Jesi Ancona, Italy

[2] Univ Nis, Med Fac, Clin Ctr, Dept Pediat Rheumatol, Bul Zoran Djindjic 81, Nish 18000, Serbia

[3] Univ Brescia, ASST, Spedali Civili Brescia, Div Rheumatol,Dept Clin & Expt Sci, Piazzale Spedali Civili 1, I-25123 Brescia, Italy

[4] Univ Genoa, IRCCS San Martino, Dept Internal Med, Res Lab, Largo R Benzi 10, I-16132 Genoa, Italy

[5] Univ Genoa, IRCCS San Martino, Dept Internal Med, Div Clin Rheumatol, Largo R Benzi 10, I-16132 Genoa, Italy

[6] Univ Med & Pharm Carol Davila, Sf Maria Hosp, Dept Internal Med & Rheumatol, Blvd Ion Mihalache 37-39,Sect 1, Bucharest 020021, Romania

[7] Inst Rheumatol, Resavska 69, Belgrade 11000, Serbia

[8] Paula Stradina Clin Hosp, Div Rheumatol, Pilsonu 13,Nr 26,Corpuss 10, LV-1001 Riga, Latvia

[9] Hosp Univ Canarias, Serv Reumatol, Planta 5,Ofra S-N La Cuesta, Santa Cruz De Tenerife 38320, Spain

[10] Mil Inst Med, Dept Internal Med & Rheumatol, Szaserow 128, PL-04141 Warsaw, Poland

[11] Vilnius Univ, Rheumatol Ctr Santariskiu 2, LT-08406 Vilnius, Lithuania

[12] RSI Ctr Inovat Med, Santariskiu 5, LT-08410 Vilnius, Lithuania

[13] Sci Res Inst Rheumatol VA Nasonova, Karshirskoe Shosse 34A, Moscow 115522, Russia

[14] Sisters Mercy Clin Hosp Ctr Univ, Phys & Rehabil Med, Dept Rheumatol, Vinogradska 29, Zagreb 10000, Croatia

[15] Univ Zagreb, Sch Med, Clin Hosp Dubrava, Dept Clin Immunol & Rheumatol, Ave Gojka Suska 6, Zagreb 10000, Croatia

[16] Natl Inst Rheumat Dis, Nabrezie Ivana Krasku 4, SK-92101 Piestany 4, Slovakia

[17] East Tallinn Cent Hosp, Dept Rheumatol, Ravi St 18, EE-10138 Tallinn, Estonia

[18] Sao Joao Hosp Ctr, Rheumatol Dept, Alameda Prof Hernani Monteiro, P-42000 Porto, Portugal

[19] FMUP, Alameda Prof Hernani Monteiro, P-42000 Porto, Portugal

[20] Med Univ Sofia, UMHAT St Iv Rilski, Dept Rheumatol, Urvich St 13, Sofia 1612, Bulgaria

来源：

JOINT BONE SPINE | 2018年 / 85卷 / 03期

关键词：

Rheumatoid arthritis; RAID; Disease activity; Patient-reported outcomes; COLLEGE-OF-RHEUMATOLOGY; SELF-REPORT QUESTIONNAIRES; AMERICAN-COLLEGE; REPORTED OUTCOMES; PSYCHOMETRIC PROPERTIES; RESPONSE CRITERIA; CLINICAL-TRIALS; VALIDATION; INDEX; RECOMMENDATIONS;

D O I：

10.1016/j.jbspin.2017.05.020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To assess the validity of the rheumatoid arthritis impact of disease (RAID) for measuring disease activity of rheumatoid arthritis (RA) and to determine cut-off values for defining the disease activity states. Methods: A total of 622 RA patients from an European database have been included. Cross-validation was based on assessment of convergent and discriminant validity. Optimal cut-offs were determined against external criteria by calculating the respective 25th and 75th percentiles mean values of RAID. External criteria included definitions for remission (REM), low disease activity (LDA), moderate disease activity (MDA) and high disease activity (HDA), cut-offs of the 28-joint disease activity score-C-reactive protein (DAS28-CRP) score. Results: The RAID showed a moderate degree of correlation with respect to DAS28-CRP (rho = 0.417; P < 0.0001). The receiver operating characteristic (ROC) curves to discriminate the ability of RAID to distinguish patients with active and non-active disease was very good with an area under the curve (AUC) of 0.847 (95% confidence interval [CI]: 0.816 to 0.878; P < 0.0001). Based on the distributions of RAID in the different disease activity groups, we propose the following cut-off values for REM: RAID <= 3; for LDA: RAID >3 and <= 4; for MDA: RAID >4 and <= 6; for HDA: RAID >6. Mean RAID differed significantly between patients classified as REM, LDA, MDA or HDA (P = 0.001). Conclusions: The cut-offs revealed good measurement characteristics in cross-validation analysis, had great discriminatory performance in distinguishing patients with different levels of disease activity and are suited for widespread use in everyday practice application and research. (C) 2017 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：317 / 322

页数：6

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