IBX-promoted domino reaction of α-hydroxy amides: a facile one-pot synthesis of isatins

被引：11

作者：

Wang, Yaoling ^{[1
]}

Cheng, Xu ^{[1
]}

Zhan, Zhen ^{[1
]}

Ma, Xiaojun ^{[1
]}

Nie, Ruifang ^{[1
]}

Hai, Li ^{[1
]}

Wu, Yong ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist,Dept Med Chem, Chengdu 610041, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 04期

基金：

中国国家自然科学基金;

关键词：

O-IODOXYBENZOIC ACID; ORGANIC-SYNTHESIS; BIOLOGICAL EVALUATION; SUBSTITUTED ISATINS; IODINE(V) REAGENTS; CARBONYL-COMPOUNDS; DERIVATIVES; OXIDATION; SYSTEMS; DESIGN;

D O I：

10.1039/c5ra25036f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and temperature-controlled oxidation of alpha-hydroxy amides in the presence of IBX is described. The divergent one-pot synthesis of isatins and alpha-formyl amides was achieved in good to excellent yields undermetal-free conditions. And these two mild methods can tolerate a variety of functional groups, and are operationally simple.

引用

页码：2870 / 2874

页数：5