IBX-promoted domino reaction of α-hydroxy amides: a facile one-pot synthesis of isatins

被引：11
作者：
Wang, Yaoling [1 ]
Cheng, Xu [1 ]
Zhan, Zhen [1 ]
Ma, Xiaojun [1 ]
Nie, Ruifang [1 ]
Hai, Li [1 ]
Wu, Yong [1 ]
机构：
[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist,Dept Med Chem, Chengdu 610041, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 04期
基金：
中国国家自然科学基金;
关键词：
O-IODOXYBENZOIC ACID; ORGANIC-SYNTHESIS; BIOLOGICAL EVALUATION; SUBSTITUTED ISATINS; IODINE(V) REAGENTS; CARBONYL-COMPOUNDS; DERIVATIVES; OXIDATION; SYSTEMS; DESIGN;
D O I：
10.1039/c5ra25036f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and temperature-controlled oxidation of alpha-hydroxy amides in the presence of IBX is described. The divergent one-pot synthesis of isatins and alpha-formyl amides was achieved in good to excellent yields undermetal-free conditions. And these two mild methods can tolerate a variety of functional groups, and are operationally simple.
引用
收藏
页码：2870 / 2874
页数：5
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