Transmission-blocking immunity to Plasmodium falciparum in malaria-immune individuals is associated with antibodies to the gamete surface protein Pfs230

被引：58

作者：

Healer, J ^{[1
]}

McGuinness, D ^{[1
]}

Carter, R ^{[1
]}

Riley, E ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Cell Anim & Populat Biol, Div Biol Sci, Ashworth Labs, Edinburgh EH9 3JT, Midlothian, Scotland

来源：

PARASITOLOGY | 1999年 / 119卷

基金：

英国惠康基金;

关键词：

transmission-blocking immunity; Plasmodium falciparum; Pfs230; enhancement of transmission; malaria-endemic sera;

D O I：

10.1017/S0031182099005041

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Malaria-immune human sera were tested for their ability to affect the infectivity of Plasmodium falciparum gametocytes to Anopheles stephensi mosquitoes. Transmission-reducing effects of the sera were associated with the presence of antibodies to the gamete surface protein, Pfs230. Enhancement of transmission, manifest as elevated numbers of oocysts relative to controls, was observed fora number of sera, but was not found to be associated with antibodies against Pfs230. These results confirm that Pfs230 is a possible candidate for inclusion in a transmission-blocking malaria vaccine.

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收藏

页码：425 / 433

页数：9

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