Oxy-peptide nucleic acid with a pyrrolidine ring that is configurationally optimized for hybridization with DNA

被引：26

作者：

Kitamatsu, M ^{[1
]}

Shigeyasu, M ^{[1
]}

Okada, T ^{[1
]}

Sisido, M ^{[1
]}

机构：

[1] Okayama Univ, Fac Engn, Dept Biosci & Biotechnol, Okayama 7008530, Japan

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 10期

关键词：

D O I：

10.1039/b401057d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four stereoisomers of oxy-peptide nucleic acids containing ether linkages in the main chain and conformationally-restricted pyrrolidine rings (pyrrolidine-based oxy-PNA = POPNA) were newly synthesized and investigated for binding to DNA. CiS-L-POPNA with 9 adenine bases formed the most stable hybrid with dT(9). The POPNA showed high sequence specificity similar to that of the Nielsen-type PNA and sharper melting behavior in hybridization with DNA than the Nielsen-type PNA.

引用

页码：1208 / 1209

页数：2

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