Loss of atheroprotective effect of estradiol in immunodeficient mice.

被引：29

作者：

Elhage, R

Clamens, S

Reardon-Alulis, C

Getz, GS

Fievet, C

Maret, A

Arnal, JF

Bayard, F

机构：

[1] Inst L BUGNARD, INSERM, U397, F-31054 Toulouse, France

[2] Inst Pasteur, SERLIA, INSERM, U315, F-59019 Lille, France

[3] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

来源：

ENDOCRINOLOGY | 2000年 / 141卷 / 01期

关键词：

D O I：

10.1210/en.141.1.462

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Estradiol significantly decreases fatty streak formation in the aortic root of chow-fed apolipoprotein E-deficient mice. In contrast, immunodeficient mice with homozygous disruption at the recombinase activating gene 2 loci present fatty streak development that is insensitive to estradiol. Lymphocytes thus appear to be required for development of the atheroprotective effect of estradiol in this mouse model.

引用

收藏

页码：462 / 465

页数：4

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