About Face: Molecular Aberrations in Head and Neck Mucosal Melanomas

被引：4

作者：

Shoushtari, Alexander N. ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[2] Weill Cornell Med Coll, New York, NY USA

来源：

CLINICAL CANCER RESEARCH | 2019年 / 25卷 / 12期

关键词：

THERAPY;

D O I：

10.1158/1078-0432.CCR-19-0658

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Detailed molecular characterization of a large cohort of mucosal melanomas, most arising from head and neck primaries, suggests that chromosomal translocations and other complex rearrangements have prognostic importance. CDK4 amplification is a frequent event in these rare tumors, and CDK4/6 inhibition may represent a rational clinical trial strategy.

引用

页码：3473 / 3475

页数：3

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