Metastatic Insulinoma Controlled by Targeted Radionuclide Therapy With 177Lu-DOTATATE in a Patient With Solitary Kidney and MEN-1 Syndrome

被引：11

作者：

Novruzov, Fuad ^{[1
]}

Mehmetbeyli, Leyla ^{[1
]}

Aliyev, Jamil A. ^{[2
]}

Abbasov, Bahadur ^{[3
]}

Mehdi, Elnur ^{[1
]}

机构：

[1] Natl Oncol Ctr, Dept Nucl Med, M Xiyabani St 137, AZ-1011 Baku, Azerbaijan

[2] Natl Oncol Ctr, Dept Gen Surg, Baku, Azerbaijan

[3] Natl Oncol Ctr, Dept Pathol, Baku, Azerbaijan

来源：

CLINICAL NUCLEAR MEDICINE | 2019年 / 44卷 / 06期

关键词：

neuroendocrine tumors; MEN-1; malignant insulinoma; Lu-177-DOTATATE; PET/CT; PRRT; TOLERABILITY; TUMOR;

D O I：

10.1097/RLU.0000000000002500

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 54-year-old man with multiple endocrine neoplasia type 1 had previous history of parathyroid surgery and left thyroid lobectomy 5 years earlier, and was referred for recurrent hypoglycemic episodes. Ga-68-DOTATATE PET/CT had showed multiple lesions in the right lung, liver, and pancreas. Biopsy from pancreas revealed low-grade neuroendocrine neoplasia. After 2 fractions of Lu-177-DOTATATE therapy, the size of lesions and its activity reduced on the Ga-68-DOTATATE scan and the hypoglycemic episodes manifested every day have scaled down to 1 time over 1-year follow-up. Herein, we report a case of malignant insulinoma successfully treated with radiolabeled somatostatin receptor therapy using Lu-177-DOTATATE.

引用

页码：E415 / E417

页数：3

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